{"id":"W2952185218","doi":"10.1021/jo9912909","title":"Design of Novel Derivatives of Phosphonoformate (Foscarnet) as Prodrugs and Antiviral Agents","year":2000,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Organophosphorus compounds synthesis","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Foscarnet; Prodrug; Pharmacology; Biochemistry; Ganciclovir","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003555928,0.000539173,0.000460092,0.000366346,0.0001851843,0.0003404746,0.0005679252,0.0004706678,0.003370174],"category_scores_gemma":[0.0002188651,0.000317982,0.0004646336,0.0002053673,0.0001530516,0.0004617284,0.0002465091,0.0005116396,0.001004565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005231393,"about_ca_system_score_gemma":0.0003757035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006254015,"about_ca_topic_score_gemma":0.001741883,"domain_scores_codex":[0.9998635,0.00002479905,0.00001463391,0.00002421373,0.00003367956,0.00003904856],"domain_scores_gemma":[0.999929,0.00000947629,0.00001482511,0.000004272602,0.00001958487,0.00002295351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009837291,0.0006523658,0.0002975464,0.0005433091,0.00006354147,0.0005885372,0.0001416505,0.004566484,0.945311,0.003229031,0.001589222,0.04203361],"study_design_scores_gemma":[0.0008645178,0.007390664,0.001038661,0.00009620604,0.0001341173,0.0007426938,0.00008148013,0.009222507,0.9309692,0.0006437994,0.04876715,0.00004902111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9251671,0.01507384,0.03117704,0.0009560952,0.0005143889,0.001985272,0.0009757584,0.000349597,0.02380094],"genre_scores_gemma":[0.9405825,0.01134126,0.02834655,0.0004744391,0.00006484082,0.0004567787,0.001323573,0.00007607673,0.01733398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003370174,"threshold_uncertainty_score":0.01127434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286174564620204,"score_gpt":0.219402845325366,"score_spread":0.206541099679164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}