{"id":"W2952187175","doi":"10.1002/jhet.5570410218","title":"Synthesis of dialkyl 1,4‐dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates and alkyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates possessing a c‐4 2,4‐dioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl (uracil) substituent to determine calcium channel modulation structure‐activity relationships","year":2004,"lang":"en","type":"article","venue":"Journal of Heterocyclic Chemistry","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Pyridine; Isopropyl; Substituent; Alkyl; Medicinal chemistry; Bioisostere; Aryl; Condensation reaction; Calcium channel; Stereochemistry; Calcium; Organic chemistry; Chemical synthesis; In vitro; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009826571,0.0008163631,0.001486448,0.0003155432,0.0003761094,0.0001556968,0.0006222252,0.0007765446,0.0002727462],"category_scores_gemma":[0.003745606,0.000689489,0.0005787176,0.0005260462,0.0003344412,0.0005869877,0.0002225474,0.001096663,0.000004806931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004620349,"about_ca_system_score_gemma":0.0001453004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001215323,"about_ca_topic_score_gemma":0.00001260862,"domain_scores_codex":[0.9951153,0.0001931899,0.001933782,0.0008523733,0.001157594,0.0007477467],"domain_scores_gemma":[0.9947784,0.001361254,0.002014998,0.000697459,0.0005018068,0.0006460825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004978473,0.0003333813,0.003739979,0.0004251085,0.0002926512,0.00004141515,0.0002612946,0.007599751,0.9776568,0.000005141291,0.000008174321,0.009138489],"study_design_scores_gemma":[0.00129785,0.0001302165,0.007742637,0.0008157807,0.0004392213,0.000387623,0.0001444483,0.003981826,0.9832982,0.0009726857,0.00007695271,0.0007125849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960529,0.001184253,0.0009539939,0.0007358551,0.0001929045,0.0002345773,0.0001068925,0.00007867226,0.0004599218],"genre_scores_gemma":[0.9965297,0.0002212743,0.002226364,0.00004143225,0.000815867,0.00002469337,0.00002696885,0.0000857314,0.00002794325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008425904,"threshold_uncertainty_score":0.9995556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04115438016348796,"score_gpt":0.272148215241203,"score_spread":0.230993835077715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}