{"id":"W2952187175","doi":"10.1002/jhet.5570410218","title":"Synthesis of dialkyl 1,4‐dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates and alkyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates possessing a c‐4 2,4‐dioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl (uracil) substituent to determine calcium channel modulation structure‐activity relationships","year":2004,"lang":"en","type":"article","venue":"Journal of Heterocyclic Chemistry","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Pyridine; Isopropyl; Substituent; Alkyl; Medicinal chemistry; Bioisostere; Aryl; Condensation reaction; Calcium channel; Stereochemistry; Calcium; Organic chemistry; Chemical synthesis; In vitro; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601428,0.0004069995,0.000347525,0.0001814752,0.0001609107,0.0001931135,0.0003614243,0.0002855991,0.001353889],"category_scores_gemma":[0.0002700535,0.0002169559,0.0002173325,0.0002049262,0.0001642481,0.0002589886,0.0001858075,0.0003545311,0.0005979001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005513285,"about_ca_system_score_gemma":0.000538172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000635042,"about_ca_topic_score_gemma":0.001297157,"domain_scores_codex":[0.9997993,0.00002701648,0.00002428492,0.0000421331,0.00005776309,0.00004939971],"domain_scores_gemma":[0.999765,0.00002177402,0.00006587272,0.00003242117,0.00004272768,0.00007209687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008802705,0.00001989942,0.00004575973,0.00007088792,0.000005479892,0.00002418647,0.0000109404,0.0001335877,0.998054,0.0001684088,0.00002915283,0.001349628],"study_design_scores_gemma":[0.00002047471,0.0002241116,0.0004268777,0.00000227139,0.000007486983,0.00003674172,0.000003151012,0.0001989148,0.9970316,0.00001069902,0.002033059,0.000004730247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820746,0.003110869,0.008909292,0.0001035224,0.0001287249,0.0004022515,0.00123269,0.0001993027,0.003838702],"genre_scores_gemma":[0.9724957,0.002233736,0.01726693,0.00007314659,0.00002536863,0.0003105635,0.001217779,0.00005242449,0.006324403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001353889,"threshold_uncertainty_score":0.004529238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04115438016348796,"score_gpt":0.272148215241203,"score_spread":0.230993835077715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}