{"id":"W2952200551","doi":"10.1016/j.stem.2019.05.013","title":"Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis","year":2019,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Alberta Children's Hospital; University of Calgary; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; Medical Research Council; Fondation de l'Avenir pour la Recherche Médicale Appliquée; Cancer Research UK; Wellcome Trust; College of Natural Resources and Sciences, Humboldt State University; Hector Stiftung II; Centre National de la Recherche Scientifique; Samuel Waxman Cancer Research Foundation; Société Française de Dermatologie et de Pathologie Sexuellement Transmissible; Institut National Du Cancer; Brain Tumour Charity; Hector Stiftung; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Science Foundation Ireland; University of California, San Francisco; Pediatric Brain Tumor Foundation; American Cancer Society; National Institutes of Health; Université Nice Sophia Antipolis; National Institute for Health and Care Research; Alex's Lemonade Stand Foundation for Childhood Cancer; V Foundation for Cancer Research","keywords":"Medulloblastoma; Biology; Stem cell; Cancer research; Carcinogenesis; Germline; Progenitor cell; Transcriptome; PTCH1; Neuroepithelial cell; Neural stem cell; Genetics; Cancer; Sonic hedgehog; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001505061,0.0003059587,0.0002805613,0.0001055855,0.00006592282,0.0000332332,0.0002756391,0.0001720779,0.0000274393],"category_scores_gemma":[0.000001815053,0.0003262047,0.0001194046,0.0001377581,0.00002793736,0.000005538561,0.0001484248,0.0001340509,0.0001647636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004246893,"about_ca_system_score_gemma":0.00003863016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001996549,"about_ca_topic_score_gemma":0.00001085717,"domain_scores_codex":[0.9982787,0.00008639852,0.0003860053,0.0006223058,0.0001797258,0.0004468998],"domain_scores_gemma":[0.9992067,0.00002666692,0.0001469987,0.000464597,0.00005318221,0.0001018267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002828123,0.00008252691,0.004738385,0.000198002,0.00001331495,0.00002101942,0.0001802139,0.009444078,0.9849272,0.000001886151,0.0001066394,0.0002584868],"study_design_scores_gemma":[0.000653739,0.0003422301,0.003720788,0.00004239554,0.00002004388,0.000005716015,0.0001285982,0.0006013733,0.9922818,0.000001821471,0.001854061,0.0003474527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969019,0.001115414,0.0001451985,0.000007729232,0.00056207,0.000448205,0.00002013784,0.00004183241,0.0007575213],"genre_scores_gemma":[0.9963501,0.00009671888,0.0001630016,0.00003689478,0.0002039663,0.00003667035,0.00002268247,0.00007257942,0.003017355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008842705,"threshold_uncertainty_score":0.999919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00474409027129287,"score_gpt":0.1816682943122206,"score_spread":0.1769242040409277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}