{"id":"W2952200551","doi":"10.1016/j.stem.2019.05.013","title":"Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis","year":2019,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Alberta Children's Hospital; University of Calgary; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; Medical Research Council; Fondation de l'Avenir pour la Recherche Médicale Appliquée; Cancer Research UK; Wellcome Trust; College of Natural Resources and Sciences, Humboldt State University; Hector Stiftung II; Centre National de la Recherche Scientifique; Samuel Waxman Cancer Research Foundation; Société Française de Dermatologie et de Pathologie Sexuellement Transmissible; Institut National Du Cancer; Brain Tumour Charity; Hector Stiftung; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Science Foundation Ireland; University of California, San Francisco; Pediatric Brain Tumor Foundation; American Cancer Society; National Institutes of Health; Université Nice Sophia Antipolis; National Institute for Health and Care Research; Alex's Lemonade Stand Foundation for Childhood Cancer; V Foundation for Cancer Research","keywords":"Medulloblastoma; Biology; Stem cell; Cancer research; Carcinogenesis; Germline; Progenitor cell; Transcriptome; PTCH1; Neuroepithelial cell; Neural stem cell; Genetics; Cancer; Sonic hedgehog; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638066,0.0002482221,0.0001931448,0.0003164604,0.0001417126,0.0002551767,0.0001398619,0.0001875687,0.0009692172],"category_scores_gemma":[0.0001194319,0.0001313954,0.0001603842,0.0001452448,0.0002598741,0.0001084647,0.0002801674,0.0002873495,0.0002149974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002441914,"about_ca_system_score_gemma":0.0002465547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009649566,"about_ca_topic_score_gemma":0.002463265,"domain_scores_codex":[0.9998302,0.00003465415,0.00002730814,0.00002880062,0.00005523619,0.00002382426],"domain_scores_gemma":[0.9999051,0.00001853312,0.00002773793,0.000021,0.000005272404,0.00002237162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004858212,0.00003100257,0.0005434349,0.0000152351,0.000005990844,0.00008694597,0.00002602217,0.0001827505,0.9980249,0.0002203604,0.00002370571,0.0007910411],"study_design_scores_gemma":[0.00001001061,0.0002533616,0.004194937,0.000005026985,0.0000180728,0.0003986532,0.00005384824,0.001031152,0.9905437,0.00005522024,0.003432377,0.000003707585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962893,0.000151459,0.00217217,0.00002799821,0.00001087304,0.00006238697,0.0003318497,0.00006922291,0.0008848655],"genre_scores_gemma":[0.9957343,0.0002524259,0.002168216,0.00001473377,0.00000226088,0.00003964804,0.0003576976,0.00002702506,0.001403812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009692172,"threshold_uncertainty_score":0.003242373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00474409027129287,"score_gpt":0.1816682943122206,"score_spread":0.1769242040409277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}