{"id":"W2952205472","doi":"10.1021/ol802021w","title":"Sintokamides A to E, Chlorinated Peptides from the Sponge <i>Dysidea</i> sp. that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells","year":2008,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Transactivation; Sponge; Prostate cancer; Chemistry; Androgen receptor; Androgen; Receptor; Stereochemistry; Cancer; Internal medicine; Biochemistry; Gene; Biology; Botany; Hormone; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336003,0.0001250923,0.0001565521,0.00001041141,0.00006782982,0.00000605129,0.0003030888,0.00006709812,0.00003809474],"category_scores_gemma":[0.00005692801,0.00005819428,0.0001005046,0.0001894063,0.0001679474,0.000006030374,0.00007908041,0.00009289211,0.00000138898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002785329,"about_ca_system_score_gemma":0.0000437187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007022725,"about_ca_topic_score_gemma":0.0003391345,"domain_scores_codex":[0.9991716,0.0001399187,0.0001797373,0.0002241591,0.0001344081,0.0001501612],"domain_scores_gemma":[0.9994519,0.00005991206,0.0001379099,0.0003002481,0.00002900731,0.00002096151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001011049,0.00004643981,0.04944074,0.000005494811,0.000025951,9.288481e-7,0.0003326989,0.0000177343,0.948797,3.995215e-7,0.0004382354,0.0007932655],"study_design_scores_gemma":[0.0001854628,0.0000316091,0.141476,0.00003773844,0.00001064918,0.000002551274,0.00005561921,0.000001493693,0.8574673,0.000004900554,0.0006511633,0.00007550522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951248,0.00009377754,0.00001345501,0.004239582,0.00009780754,0.0003449151,0.00007163367,0.000003494038,0.00001051272],"genre_scores_gemma":[0.998184,0.0001313348,0.00002388352,0.001541043,0.00005491199,0.00002035801,0.000005556881,0.00001130005,0.00002766787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09203529,"threshold_uncertainty_score":0.2373094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228679128870569,"score_gpt":0.1966100029900844,"score_spread":0.1843232117013787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}