{"id":"W2952205472","doi":"10.1021/ol802021w","title":"Sintokamides A to E, Chlorinated Peptides from the Sponge <i>Dysidea</i> sp. that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells","year":2008,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Transactivation; Sponge; Prostate cancer; Chemistry; Androgen receptor; Androgen; Receptor; Stereochemistry; Cancer; Internal medicine; Biochemistry; Gene; Biology; Botany; Hormone; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004406035,0.0003310908,0.0001174408,0.0001191742,0.0000840611,0.0001184465,0.00008346212,0.00009103926,0.0006991813],"category_scores_gemma":[0.00007224807,0.00007838286,0.000097852,0.0001105036,0.0001992675,0.0001053504,0.0001011875,0.0002043165,0.0001740066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00011161,"about_ca_system_score_gemma":0.0002049598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005193655,"about_ca_topic_score_gemma":0.001568064,"domain_scores_codex":[0.9999744,0.000003922142,0.000003295752,0.000004009735,0.000008276904,0.000006114664],"domain_scores_gemma":[0.9999377,0.00001178562,0.00001943332,0.000004539521,0.000007091318,0.00001960771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000151543,0.00001007065,0.0002812391,0.00005648132,0.000006019045,0.00007925121,0.00001059869,0.0001019117,0.9978265,0.00004838527,0.0000205477,0.001407376],"study_design_scores_gemma":[0.00006130928,0.0008352157,0.01361121,0.00001136628,0.0000233986,0.000664025,0.00005058414,0.0002664869,0.9787056,0.00005601985,0.005704811,0.000009926431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953342,0.001895196,0.0009198437,0.00002538955,0.00001339156,0.00003557258,0.0003010166,0.00001319496,0.001462115],"genre_scores_gemma":[0.993467,0.002246667,0.001805983,0.00004361263,0.00000883149,0.00002777797,0.0008360016,0.000006971627,0.001557146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006991813,"threshold_uncertainty_score":0.002339005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228679128870569,"score_gpt":0.1966100029900844,"score_spread":0.1843232117013787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}