{"id":"W2952221338","doi":"10.1101/173252","title":"BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Genome instability; Bloom syndrome; Biology; Genetics; Gene; Sister chromatid exchange; Sister chromatids; Genome; Helicase; DNA; DNA damage; Chromosome; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001954193,0.0002323226,0.0002297848,0.0002597765,0.0001108166,0.0003130993,0.0002328182,0.0003115052,0.001437241],"category_scores_gemma":[0.0002041222,0.0001235497,0.0001434541,0.0001191626,0.0002271882,0.00009597383,0.000254122,0.0003901679,0.0005404137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002949116,"about_ca_system_score_gemma":0.0001596645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004288449,"about_ca_topic_score_gemma":0.0005547659,"domain_scores_codex":[0.9998538,0.00003018267,0.00001319181,0.00004140705,0.00003649757,0.00002481663],"domain_scores_gemma":[0.9998228,0.00004636633,0.00005500668,0.00003202899,0.00001281809,0.00003084466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003178098,0.000004142798,0.00008362369,0.000008901776,0.000001226866,0.00001382104,0.000003421085,0.00002893559,0.9994369,0.00003058569,0.00002149958,0.0003350886],"study_design_scores_gemma":[0.000005577892,0.00002419485,0.001073125,0.000001960829,0.000001983475,0.00004666896,0.000005155013,0.0004800551,0.9972402,0.00003115353,0.001088898,0.000001005581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908568,0.0006676094,0.005798088,0.0001783547,0.00002833221,0.00001562063,0.0008741065,0.0003806987,0.001200289],"genre_scores_gemma":[0.9931512,0.0001614041,0.003406893,0.000057306,0.000006600305,0.00001016014,0.0007152556,0.00008550579,0.002405666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001437241,"threshold_uncertainty_score":0.004808068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322975474832155,"score_gpt":0.2651955534010313,"score_spread":0.2519657986527098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}