{"id":"W2952308002","doi":"10.1016/j.fct.2019.110581","title":"Hexabromocyclododecane (HBCD): A case study applying tiered testing for human health risk assessment","year":2019,"lang":"en","type":"article","venue":"Food and Chemical Toxicology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada","keywords":"Hexabromocyclododecane; In silico; Human health; In vivo; Computational biology; Toxicogenomics; Computer science; Fire retardant; Toxicology; Biology; Chemistry; Medicine; Biotechnology; Environmental health; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002140434,0.0004717377,0.0004179081,0.0007717962,0.0008054878,0.0009959281,0.0006168507,0.001210418,0.001072113],"category_scores_gemma":[0.002018722,0.0001785035,0.0007297174,0.0009722568,0.0006077836,0.0003877422,0.0007088228,0.0004940357,0.0001732403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001616161,"about_ca_system_score_gemma":0.001477821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01851312,"about_ca_topic_score_gemma":0.03196091,"domain_scores_codex":[0.9981883,0.0006269966,0.00006689111,0.0002738887,0.0006962833,0.0001476975],"domain_scores_gemma":[0.9981952,0.0008334892,0.0001984777,0.0002217604,0.0004569201,0.00009405691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003905094,0.003850585,0.2244799,0.002150828,0.0007273167,0.02201097,0.002938271,0.0887936,0.3551762,0.009484662,0.004770183,0.2817124],"study_design_scores_gemma":[0.0003582501,0.02084747,0.1201191,0.000283344,0.001079691,0.01818141,0.006703895,0.0757653,0.668598,0.01075541,0.07695498,0.0003532803],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581493,0.001563584,0.02875759,0.0007619405,0.00003987575,0.0008073293,0.001439335,0.0001293132,0.008351795],"genre_scores_gemma":[0.9525375,0.001823724,0.04090128,0.0003817065,0.00001324827,0.0001222378,0.0004845886,0.00003177458,0.003703938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01851312,"threshold_uncertainty_score":0.0368107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0291623074093663,"score_gpt":0.3172960193993377,"score_spread":0.2881337119899714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}