{"id":"W2952314051","doi":"10.1161/atvb.37.suppl_1.626","title":"Abstract 626: Apabetalone (Rvx-208), a Selective Bet Protein Inhibitor, Reduces Expression of Acute Phase Response Markers <i>in vitro</i> and in Patients With Cardiovascular Disease and Chronic Kidney Disease","year":2017,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Acute-phase protein; Serum amyloid A; Medicine; Inflammation; Kidney disease; Internal medicine; Diabetes mellitus; Immunology; Bromodomain; Post-hoc analysis; Endocrinology; Biology; Epigenetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008663024,0.0004756181,0.0003300266,0.0001440162,0.00008287967,0.0001723903,0.0001210456,0.0002267978,0.004931787],"category_scores_gemma":[0.00006642704,0.0001006778,0.0002241974,0.0001208576,0.0001173315,0.0001020329,0.00009481393,0.0005756793,0.0007307931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001265993,"about_ca_system_score_gemma":0.000139201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003328308,"about_ca_topic_score_gemma":0.0004541548,"domain_scores_codex":[0.9999545,0.000008688627,0.000004429869,0.00000962136,0.00001080382,0.0000119086],"domain_scores_gemma":[0.9999632,0.000005610661,0.0000102662,0.000002615338,0.000005136293,0.00001320167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006814663,0.000600029,0.0005018634,0.0002565469,0.00005000196,0.0000721824,0.00001024882,0.00008481175,0.9753939,0.00004396666,0.0007138536,0.01545786],"study_design_scores_gemma":[0.002832203,0.02213998,0.02437415,0.00003101279,0.0001938654,0.0006795044,0.00002626342,0.0006984348,0.9420375,0.00008176245,0.006891796,0.00001366333],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876117,0.005718512,0.001355749,0.000266339,0.0001879617,0.0001115996,0.00188441,0.0002297356,0.002633933],"genre_scores_gemma":[0.9857196,0.002692093,0.001717964,0.0003318588,0.00009097064,0.00009818558,0.002691817,0.00002706376,0.006630461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004931787,"threshold_uncertainty_score":0.01649845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009626891635678732,"score_gpt":0.2454028680550391,"score_spread":0.2357759764193604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}