{"id":"W2952326196","doi":"10.1101/677153","title":"Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia; Lawson Health Research Institute; Western University","funders":"National Institute of Child Health and Human Development; National Institute on Alcohol Abuse and Alcoholism; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; Clinical Science Research and Development; National Institutes of Health; Congressionally Directed Medical Research Programs; Bill and Melinda Gates Foundation; ZonMw; National Alliance for Research on Schizophrenia and Depression; Canadian Institute for Military and Veteran Health Research; Chinese Academy of Sciences; Division of Research Capacity Development; Deutsche Forschungsgemeinschaft; National Research Foundation; Yale Center for Clinical Investigation, Yale School of Medicine; Institute for Clinical and Translational Research, University of Wisconsin, Madison; Medical Research and Materiel Command; National Natural Science Foundation of China; Georgia Clinical and Translational Science Alliance; Waisman Center; Yale University; U.S. Department of Veterans Affairs; Office of Research and Development; Michael J. Fox Foundation for Parkinson's Research; Traumatic Brain Injury Center of Excellence; South African Medical Research Council; U.S. Department of Defense; National Center for PTSD, U.S. Department of Veterans Affairs; Canadian Institutes of Health Research; National Science Foundation","keywords":"Fractional anisotropy; White matter; Corpus callosum; Diffusion MRI; Neuroimaging; Psychology; Depression (economics); Brain Structure and Function; Tractography; Psychiatry; Traumatic stress; Confounding; Clinical psychology; Medicine; Neuroscience; Internal medicine; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001959252,0.0004593773,0.0005396885,0.001084047,0.0009608833,0.0009093245,0.0008931571,0.0007991288,0.001603394],"category_scores_gemma":[0.004525277,0.0004098291,0.001209173,0.00186567,0.0004857759,0.0004530717,0.001982977,0.0007075537,0.000205062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004213975,"about_ca_system_score_gemma":0.0004905188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02333885,"about_ca_topic_score_gemma":0.02500803,"domain_scores_codex":[0.9988977,0.0002384586,0.0001177375,0.0004598698,0.0001760022,0.0001102271],"domain_scores_gemma":[0.9974713,0.0003247446,0.001111673,0.0004199518,0.0003835886,0.0002887815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004287616,0.0000336457,0.9940082,0.00006854532,0.001595407,0.0001458568,0.0003517561,0.0001397199,0.0007338707,0.00005539778,0.0006100581,0.00182879],"study_design_scores_gemma":[0.0000256362,0.00005669418,0.9985826,0.00001864656,0.0003623317,0.000201689,0.0002558793,0.00006780507,0.00009722108,0.00004384418,0.0002791309,0.000008427962],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958147,0.0003598193,0.0001934045,0.0001177769,0.000009489499,0.0000171624,0.003260438,0.000009882464,0.0002172461],"genre_scores_gemma":[0.996348,0.0001694916,0.0002437678,0.00006361307,0.00001226508,0.00003469855,0.002950458,0.00001419665,0.0001636558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02333885,"threshold_uncertainty_score":0.04640603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758380025829856,"score_gpt":0.2695405181930554,"score_spread":0.2519567179347568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}