{"id":"W2952365135","doi":"10.1016/j.dld.2019.05.002","title":"Effectiveness and safety of Ustekinumab for Crohn's disease; systematic review and pooled analysis of real-world evidence","year":2019,"lang":"en","type":"review","venue":"Digestive and Liver Disease","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Janssen Biotech; Canadian Association of Gastroenterology; Canadian Institutes of Health Research; AbbVie; Takeda Oncology; Pfizer","keywords":"Ustekinumab; Medicine; Crohn's disease; Meta-analysis; Crohn disease; Pooled analysis; Internal medicine; Disease; Adalimumab","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005270016,0.0004704746,0.002519498,0.0002351821,0.00006314324,0.00002169178,0.0001884837,0.000112533,0.000008453131],"category_scores_gemma":[0.0007845372,0.0003764764,0.0006991439,0.0002877594,0.0002517235,0.00001745825,0.0002144277,0.00007287378,8.590139e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003240975,"about_ca_system_score_gemma":0.0003713644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001779148,"about_ca_topic_score_gemma":0.00001078698,"domain_scores_codex":[0.9974759,0.0006669794,0.0007281755,0.0007413538,0.0001764659,0.0002110936],"domain_scores_gemma":[0.9973746,0.0005277342,0.0007479715,0.0006738564,0.0002800729,0.0003957895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"observational","study_design_scores_codex":[0.0007001022,0.00006215512,0.003922762,0.9885413,0.003990644,0.00005036435,0.00001032976,0.000002675934,0.000003118387,0.0001459589,0.00002028175,0.002550329],"study_design_scores_gemma":[0.0004233445,0.00007563825,0.4225462,0.3739841,0.2013092,0.000001347844,0.000005522989,0.00003358095,0.000001498559,0.0000077225,0.001111299,0.0005005623],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003533058,0.9887044,0.00004958197,0.000004133516,0.00002377935,0.00518732,0.00247794,0.000005741822,0.00001400927],"genre_scores_gemma":[0.0173149,0.9813443,0.00001153146,0.0000324607,0.00002077058,0.0005259754,0.0005841534,0.00003807804,0.0001278728],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6145572,"threshold_uncertainty_score":0.9998687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178346680384892,"score_gpt":0.3131570353946133,"score_spread":0.2913735685907644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}