{"id":"W2952369951","doi":"10.1002/chin.201016126","title":"ChemInform Abstract: Synthesis and Biological Evaluation of Salicylic Acid and N‐Acetyl‐2‐carboxybenzenesulfonamide Regioisomers Possessing a N‐Difluoromethyl‐1,2‐dihydropyrid‐2‐one Pharmacophore: Dual Inhibitors of Cyclooxygenases and 5‐Lipoxygenase with Antiinflammatory Activity.","year":2010,"lang":"en","type":"article","venue":"ChemInform","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Pharmacophore; Structural isomer; Chemistry; Salicylic acid; Dual (grammatical number); Computational biology; Stereochemistry; Information retrieval; Combinatorial chemistry; Computer science; Biochemistry; Biology; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002715955,0.0008448601,0.0004596296,0.0004714314,0.0002710396,0.0003076372,0.0004207086,0.0004330259,0.007750383],"category_scores_gemma":[0.0002053177,0.0002879114,0.0003424622,0.0003870185,0.0002192085,0.0003689356,0.0002251736,0.0004775374,0.002243898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004043439,"about_ca_system_score_gemma":0.0008536491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089266,"about_ca_topic_score_gemma":0.001937591,"domain_scores_codex":[0.9998441,0.0000293728,0.00001237225,0.00002221052,0.0000597361,0.00003220662],"domain_scores_gemma":[0.9999176,0.000006795593,0.00002149376,0.00000833819,0.00001876368,0.00002702529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002344096,0.0004649342,0.0002152178,0.0007979428,0.00006702034,0.0002520518,0.00005364123,0.00118735,0.9526548,0.001015386,0.003248557,0.03769897],"study_design_scores_gemma":[0.0007609278,0.004780803,0.001792193,0.00004239276,0.0001136562,0.0005238341,0.00002316786,0.0006537609,0.9626542,0.0001705371,0.02845063,0.00003389905],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8493891,0.05847233,0.01554991,0.0009573184,0.0006441533,0.001047513,0.01027401,0.0009311723,0.06273446],"genre_scores_gemma":[0.9275554,0.02535461,0.009791313,0.0004259791,0.0001798181,0.0001951956,0.008182049,0.0001000383,0.02821568],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.007750383,"threshold_uncertainty_score":0.02592766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02171823666741798,"score_gpt":0.2722302273428265,"score_spread":0.2505119906754086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}