{"id":"W2952375224","doi":"10.1097/01.hs9.0000562928.03733.42","title":"PS1161 EFFICACY AND SAFETY OF IBRUTINIB IN RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS PREVIOUSLY TREATED WITH VENETOCLAX IN THE MURANO STUDY","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Venetoclax; Medicine; Bendamustine; Ibrutinib; Internal medicine; Rituximab; Hazard ratio; Chronic lymphocytic leukemia; Population; Oncology; Refractory (planetary science); Clinical endpoint; Confidence interval; Leukemia; Randomized controlled trial; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00100904,0.0003304979,0.0008752426,0.0001993836,0.0002118557,0.0006517352,0.0002711378,0.0003466283,0.001274997],"category_scores_gemma":[0.001177274,0.0001620589,0.0005706632,0.0002780299,0.0002355004,0.0003067155,0.0003077786,0.00074306,0.0001918635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005419644,"about_ca_system_score_gemma":0.0004099344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001060722,"about_ca_topic_score_gemma":0.002294326,"domain_scores_codex":[0.9996656,0.0001695908,0.00001824002,0.00006040318,0.00004203885,0.00004404604],"domain_scores_gemma":[0.9994168,0.0001191231,0.0002608408,0.00004404411,0.00002789854,0.0001313206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4711225,0.003968007,0.3584829,0.000941361,0.003047551,0.0004670933,0.0004555101,0.001648962,0.02012877,0.0002504393,0.004685668,0.1348013],"study_design_scores_gemma":[0.08221079,0.08712573,0.8180689,0.0001265282,0.001918518,0.0007386805,0.0001500094,0.001689726,0.001471401,0.0001885358,0.006270446,0.00004084728],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968423,0.001849067,0.00002656156,0.00007847708,0.00001817865,0.00004866228,0.0002514432,0.000007558466,0.0008778349],"genre_scores_gemma":[0.9983791,0.0005111629,0.00005079743,0.00008971449,0.00003383321,0.00004386874,0.0005651104,0.000002563422,0.0003238865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274997,"threshold_uncertainty_score":0.005336404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036038918704425,"score_gpt":0.2625796229925551,"score_spread":0.2522192338055109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}