{"id":"W2952376212","doi":"10.1371/journal.pbio.3000309","title":"AMPK regulates germline stem cell quiescence and integrity through an endogenous small RNA pathway","year":2019,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Germline; Cell biology; AMPK; RNA interference; Caenorhabditis elegans; Piwi-interacting RNA; Chromatin; Protein kinase A; Somatic cell; Stem cell; RNA; Genetics; Kinase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000676608,0.0001635773,0.0001040562,0.0001682448,0.0001604127,0.0003251521,0.0001532177,0.0001599526,0.0008127785],"category_scores_gemma":[0.00007391965,0.0001059682,0.0001027888,0.00005215818,0.0002645509,0.000188708,0.0001910028,0.0002363665,0.0002132801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021039,"about_ca_system_score_gemma":0.0001502247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002076763,"about_ca_topic_score_gemma":0.00061981,"domain_scores_codex":[0.9999543,0.00000593103,0.000003480367,0.00001420259,0.00001325355,0.000008784633],"domain_scores_gemma":[0.9999396,0.000007602173,0.00002557588,0.000005974508,0.000006386536,0.0000147658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000310978,0.000004027797,0.0001467366,0.00001205206,0.00000138541,0.00002765888,0.000006068536,0.00004795055,0.9985133,0.0003357758,0.00001947014,0.0008545212],"study_design_scores_gemma":[0.00001424872,0.0001115557,0.009272806,0.000008396625,0.00001206957,0.0001346277,0.00003371809,0.0015613,0.9852203,0.0003944994,0.003230473,0.000005929767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894053,0.001845281,0.005376648,0.0001774986,0.00004552255,0.00001061222,0.0001810861,0.000158677,0.002799329],"genre_scores_gemma":[0.9957938,0.0006436947,0.001494396,0.00004609611,0.00001070564,0.000008760281,0.0001034535,0.00001942256,0.001879797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008127785,"threshold_uncertainty_score":0.002718985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03505404033250891,"score_gpt":0.2258415740469762,"score_spread":0.1907875337144672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}