{"id":"W2952436256","doi":"10.1016/j.molcel.2019.04.008","title":"Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins","year":2019,"lang":"en","type":"article","venue":"Molecular Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; National Institute on Drug Abuse; National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; James B. Pendleton Charitable Trust; University of California, San Francisco; American Society for Microbiology","keywords":"RNA polymerase II; Biology; Acetylation; Phosphorylation; Cell biology; Transcription (linguistics); Crosstalk; Heptad repeat; CTD; Transcription factor II F; Molecular biology; Biochemistry; RNA; RNA polymerase; Peptide sequence; Gene; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003857351,0.0005938199,0.0003157209,0.0002602219,0.0003217888,0.0009832503,0.0003980286,0.0004116067,0.002296512],"category_scores_gemma":[0.0003062343,0.0003285103,0.0004028403,0.0001607541,0.0004215475,0.0005293203,0.0005624652,0.0006633534,0.0009094476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005217211,"about_ca_system_score_gemma":0.0002731825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003233258,"about_ca_topic_score_gemma":0.0006904138,"domain_scores_codex":[0.999696,0.00004979179,0.00002455099,0.00009430457,0.00004530076,0.00009012433],"domain_scores_gemma":[0.9997312,0.00004366186,0.00006524044,0.00004868779,0.00002943754,0.00008173071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003702053,0.0000236728,0.0007154278,0.00004369431,0.00001110041,0.0001985707,0.00002158994,0.0001332833,0.995529,0.0007771115,0.0001511302,0.002025185],"study_design_scores_gemma":[0.00003665159,0.0001329299,0.01858499,0.00001244066,0.00001595872,0.0005171957,0.00008774727,0.00209172,0.9750429,0.0004690759,0.002992133,0.0000163452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809202,0.005870399,0.006320953,0.000835416,0.0002141315,0.00002779278,0.0003844818,0.0002180908,0.005208616],"genre_scores_gemma":[0.9945028,0.0009685243,0.001542544,0.00009491321,0.00004453973,0.00001276171,0.0002932678,0.00002861309,0.00251199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002296512,"threshold_uncertainty_score":0.007682562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004870608617412463,"score_gpt":0.2342249921908012,"score_spread":0.2293543835733887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}