{"id":"W2952467613","doi":"10.1021/ol800923q","title":"Asymmetric Synthesis of Carboxylic Acid Derivatives Having an All-Carbon α-Quaternary Center through Cu-Catalyzed 1,4-Addition of Dialkylzinc Reagents to 2-Aryl Acetate Derivatives","year":2008,"lang":"en","type":"article","venue":"Organic Letters","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Reagent; Aryl; Quaternary carbon; Catalysis; Organic chemistry; Carboxylic acid; Carbon fibers; Combinatorial chemistry; Medicinal chemistry; Enantioselective synthesis; Alkyl","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002166091,0.0004742574,0.0008736083,0.0004841148,0.0001280601,0.0000234379,0.0007407527,0.0001691899,0.000337143],"category_scores_gemma":[0.0008417167,0.0004602212,0.0002807965,0.001466118,0.0002293471,0.0004718332,0.0002457456,0.0001961424,0.00002100393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000202226,"about_ca_system_score_gemma":0.00006190105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004109137,"about_ca_topic_score_gemma":0.00001655347,"domain_scores_codex":[0.9969797,0.0001162675,0.0008912811,0.0007546229,0.000712547,0.0005456449],"domain_scores_gemma":[0.9975905,0.0004598305,0.000683337,0.0009698236,0.0001123475,0.0001840984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000111658,0.0003610688,0.01959936,0.0001404839,0.0005955246,0.00003586178,0.0028484,0.000004659261,0.9682284,0.000004056368,0.0002528061,0.007817729],"study_design_scores_gemma":[0.0005509611,0.00004349694,0.01400738,0.0001695183,0.0002246124,0.00002375569,0.0005609892,0.00004437258,0.9838219,0.00001047246,0.00009423254,0.0004483207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996378,0.0002142505,0.0006240902,0.0005410236,0.00009002595,0.000167922,0.0001347333,0.00008987364,0.001760063],"genre_scores_gemma":[0.9974947,0.0003408662,0.001313652,0.0003594284,0.000147606,0.00005422252,0.000150041,0.0001111206,0.00002838319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0155935,"threshold_uncertainty_score":0.9997849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02300533787833335,"score_gpt":0.2394433467585723,"score_spread":0.2164380088802389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}