{"id":"W2952482267","doi":"10.1097/01.hs9.0000558668.31452.51","title":"S112 MLL FUSIONS AFFECT SPLICING TO INDUCE EXPLOITABLE METABOLIC DEPENDENCIES","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Genetics","funders":"","keywords":"PKM2; Biology; Cell biology; Warburg effect; Small hairpin RNA; Alternative splicing; Glycolysis; Cell growth; RNA splicing; Cancer research; Exon; Chemistry; Pyruvate kinase; Gene; Biochemistry; RNA; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004021848,0.0002605867,0.0005597712,0.0001479117,0.0001271321,0.00004551325,0.0002702301,0.0001755759,0.006341153],"category_scores_gemma":[0.000321758,0.0002159877,0.0001441792,0.0007701732,0.00003360528,0.0001949171,0.0003458356,0.0005705233,0.00652185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002396353,"about_ca_system_score_gemma":0.000545164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007868311,"about_ca_topic_score_gemma":0.0001928475,"domain_scores_codex":[0.9977094,0.00006603255,0.0002658389,0.0005242187,0.0006627276,0.0007717896],"domain_scores_gemma":[0.9982193,0.0001870023,0.00005149544,0.0008909793,0.0001672847,0.000483954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000309281,0.0002727736,0.08937641,0.0004236649,0.0002724923,0.0004035573,0.002024657,0.0001223255,0.8283958,0.003360623,0.06152896,0.01350945],"study_design_scores_gemma":[0.007039302,0.001399896,0.1395841,0.001156993,0.0003799865,0.0007843692,0.01166056,0.0008650949,0.4669211,0.0002410654,0.3685885,0.001378979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9360726,0.001012644,0.0002021481,0.001387261,0.0002063362,0.00119968,0.00000677752,0.0001770889,0.0597354],"genre_scores_gemma":[0.9462743,0.00008775344,0.003550934,0.001349297,0.0002805923,0.0001022243,0.00001462841,0.00007427268,0.048266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3614747,"threshold_uncertainty_score":0.9945672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0273589716298963,"score_gpt":0.3067686013490634,"score_spread":0.2794096297191671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}