{"id":"W2952482267","doi":"10.1097/01.hs9.0000558668.31452.51","title":"S112 MLL FUSIONS AFFECT SPLICING TO INDUCE EXPLOITABLE METABOLIC DEPENDENCIES","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Genetics","funders":"","keywords":"PKM2; Biology; Cell biology; Warburg effect; Small hairpin RNA; Alternative splicing; Glycolysis; Cell growth; RNA splicing; Cancer research; Exon; Chemistry; Pyruvate kinase; Gene; Biochemistry; RNA; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001675169,0.0003573648,0.0002146412,0.0001413241,0.0001388121,0.0003204143,0.0001975185,0.0004426679,0.003896695],"category_scores_gemma":[0.0001758518,0.0001262678,0.0002473237,0.0001558717,0.0002193214,0.0001384682,0.0002696092,0.0006595263,0.001032403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003149411,"about_ca_system_score_gemma":0.0001629651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000263786,"about_ca_topic_score_gemma":0.0004032885,"domain_scores_codex":[0.9998388,0.00002352249,0.00002168126,0.00003086481,0.00005844,0.00002670403],"domain_scores_gemma":[0.9998533,0.00004339742,0.00004959057,0.00001861014,0.00001133777,0.0000237688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000824306,0.00002978059,0.0001350512,0.00002239253,0.000004393769,0.0000978995,0.00001024438,0.0001209208,0.9983004,0.0001461568,0.00008551138,0.0009649171],"study_design_scores_gemma":[0.00002523845,0.0002260306,0.001193871,0.000005291316,0.00001178396,0.000357916,0.000015485,0.00126209,0.9924214,0.00007515905,0.00440159,0.000004144188],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893581,0.0005194752,0.005767625,0.0001699076,0.00006581902,0.00009175712,0.001006719,0.0003419832,0.00267859],"genre_scores_gemma":[0.9929636,0.0002253325,0.002315245,0.00007373252,0.00001012598,0.00004456632,0.001111236,0.0000973339,0.003158848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003896695,"threshold_uncertainty_score":0.01303571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0273589716298963,"score_gpt":0.3067686013490634,"score_spread":0.2794096297191671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}