{"id":"W2952488211","doi":"10.1371/journal.pgen.1006815","title":"Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function","year":2017,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; National Alliance for Research on Schizophrenia and Depression; York University; G. Harold and Leila Y. Mathers Charitable Foundation; Sleep Research Society; Leon Levy Foundation; New York University; Whitehall Foundation; Howard Hughes Medical Institute; Sleep Research Society Foundation; Alfred P. Sloan Foundation; Brain and Behavior Research Foundation","keywords":"Biology; Sleep (system call); Drosophila melanogaster; Neuroscience; Ubiquitin ligase; Mutant; Ubiquitin; Conserved sequence; Nervous system; Genetics; Gene; Cell biology; Peptide sequence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007579885,0.00008548165,0.0001386924,0.00004592012,0.0003573417,0.00002936585,0.0002114268,0.0001016984,0.00001491231],"category_scores_gemma":[0.0004957358,0.00007144394,0.0000225926,0.00003315564,0.00081561,0.00008849623,0.0001524452,0.0001427441,0.00001950342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004774566,"about_ca_system_score_gemma":0.00002349788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001868405,"about_ca_topic_score_gemma":0.000002001291,"domain_scores_codex":[0.999206,0.000143123,0.0001508829,0.0002506587,0.00009471232,0.0001546219],"domain_scores_gemma":[0.9992899,0.00007171981,0.0001259393,0.0004119158,0.00006216134,0.00003839824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001246106,0.00004421173,0.004065295,0.00004715314,0.00001087935,0.000001238172,0.00004944356,0.00001492395,0.9948269,0.0004538231,0.00001002164,0.0003515684],"study_design_scores_gemma":[0.000257677,0.0003505622,0.04556076,0.00002134625,0.00001723636,0.000006028281,0.000003161784,0.007710519,0.9443988,0.001566394,0.00003737557,0.00007012135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986451,0.0001591392,0.000004794043,0.0004937989,0.0001335827,0.0001999976,0.000004213779,0.00002127627,0.0003380855],"genre_scores_gemma":[0.9994572,0.0001424017,0.00001733676,0.0001526386,0.00007006279,0.00001204948,0.000001075334,0.00001010409,0.0001371384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05042801,"threshold_uncertainty_score":0.3005149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08906971603607845,"score_gpt":0.2718926265411005,"score_spread":0.1828229105050221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}