{"id":"W2952505260","doi":"10.3389/fchem.2019.00434","title":"Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents","year":2019,"lang":"en","type":"article","venue":"Frontiers in Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Yunnan Provincial Science and Technology Department; National Natural Science Foundation of China","keywords":"Podophyllotoxin; Cytotoxic T cell; Apoptosis; Chemistry; Topoisomerase; Biotinylation; Cell culture; MTT assay; Cancer cell; Sulforhodamine B; Cell growth; Cytotoxicity; In vivo; Biochemistry; In vitro; Pharmacology; Biology; Cancer; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000569476,0.0001852342,0.0002834908,0.00003710702,0.0000306062,0.00001400563,0.0001718736,0.000273372,0.00005922684],"category_scores_gemma":[0.0002352673,0.0001652157,0.00006086129,0.00008798223,0.0001399747,0.000007836329,0.00008876568,0.00008927874,0.000001563407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002610695,"about_ca_system_score_gemma":0.00009940568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001021008,"about_ca_topic_score_gemma":3.45543e-7,"domain_scores_codex":[0.998779,0.0001171176,0.0002378036,0.0004352508,0.0002150947,0.0002157239],"domain_scores_gemma":[0.9994607,0.00002558228,0.0001563066,0.0002290065,0.00007321936,0.00005518902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000198773,0.0001878172,0.01731798,0.00004192791,0.00007309969,0.00000191453,0.00001415298,0.0001143581,0.9799137,7.439132e-7,0.0001510018,0.001984603],"study_design_scores_gemma":[0.0007537663,0.00006397844,0.01864444,0.00005467797,0.00003056565,0.00001749972,0.0001472588,0.002718532,0.9772604,0.00002452891,0.00008136193,0.0002030082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947094,0.0007076471,0.003661959,0.00002389904,0.0001200007,0.0002997786,0.00004772749,0.000007701533,0.0004219128],"genre_scores_gemma":[0.9951652,0.0002738987,0.00435809,0.00001939754,0.00004033604,0.00001884596,0.00005995983,0.00001309962,0.00005122551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002653246,"threshold_uncertainty_score":0.6737299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666721326949613,"score_gpt":0.2558242795749115,"score_spread":0.2291570663054154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}