{"id":"W2952505260","doi":"10.3389/fchem.2019.00434","title":"Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents","year":2019,"lang":"en","type":"article","venue":"Frontiers in Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Yunnan Provincial Science and Technology Department; National Natural Science Foundation of China","keywords":"Podophyllotoxin; Cytotoxic T cell; Apoptosis; Chemistry; Topoisomerase; Biotinylation; Cell culture; MTT assay; Cancer cell; Sulforhodamine B; Cell growth; Cytotoxicity; In vivo; Biochemistry; In vitro; Pharmacology; Biology; Cancer; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343102,0.0002422499,0.0002209394,0.0001876866,0.0001006462,0.0002082545,0.0001935017,0.0002041471,0.000997897],"category_scores_gemma":[0.0001163315,0.00009935499,0.0001962962,0.0002021578,0.0001129012,0.0002541087,0.0001555137,0.0002829865,0.0002256391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002721608,"about_ca_system_score_gemma":0.0001887526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002881209,"about_ca_topic_score_gemma":0.0008449934,"domain_scores_codex":[0.9999545,0.000008546746,0.000005126251,0.000008888313,0.00001121236,0.00001178092],"domain_scores_gemma":[0.9999505,0.000004629163,0.0000161117,0.000004089814,0.00001062644,0.00001410134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000179592,0.0001269404,0.0002473644,0.0002846965,0.00001584318,0.0001568528,0.00003615108,0.001315529,0.9864545,0.0006143447,0.00007700566,0.01049111],"study_design_scores_gemma":[0.0001473815,0.003234238,0.00219596,0.0000439401,0.00006779263,0.0003181186,0.00004813924,0.002221613,0.9796031,0.0002565169,0.01184523,0.00001784295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707229,0.008318932,0.01580807,0.0002205308,0.00005448544,0.0002986474,0.0004977355,0.00008897731,0.003989725],"genre_scores_gemma":[0.9828507,0.004279088,0.009803492,0.00006995817,0.00001066564,0.00008510641,0.000360743,0.000008791786,0.002531471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000997897,"threshold_uncertainty_score":0.003338337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666721326949613,"score_gpt":0.2558242795749115,"score_spread":0.2291570663054154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}