{"id":"W2952544614","doi":"10.1021/jm990336n","title":"2‘,6‘-Dimethylphenoxyacetyl:  A New Achiral High Affinity P<sub>3</sub>-P<sub>2</sub>Ligand for Peptidomimetic-Based HIV Protease Inhibitors","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Peptidomimetic; Stereochemistry; Protease; Ligand (biochemistry); Protease inhibitor (pharmacology); HIV-1 protease; Chemical synthesis; Potency; Structure–activity relationship; Bioavailability; In vitro; Human immunodeficiency virus (HIV); Enzyme; Receptor; Biochemistry; Pharmacology; Virology; Antiretroviral therapy; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046063,0.0003119037,0.0002648232,0.0001143522,0.0001070802,0.0001933457,0.0004512052,0.0001843197,0.001399966],"category_scores_gemma":[0.00007688576,0.0001229174,0.00009914649,0.0001070723,0.0002201311,0.0002157321,0.0001865684,0.0004931441,0.0005299435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194575,"about_ca_system_score_gemma":0.0001840264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004977275,"about_ca_topic_score_gemma":0.0008790579,"domain_scores_codex":[0.9999461,0.00001379813,0.000002792309,0.000008715127,0.00001502736,0.00001365761],"domain_scores_gemma":[0.9999709,0.000004218687,0.000006753759,0.000002350152,0.000004144245,0.00001154589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004178436,0.00009250761,0.0002108133,0.0001143628,0.00001094227,0.0002873041,0.00004393824,0.000898945,0.9830468,0.0007148148,0.00030161,0.01386002],"study_design_scores_gemma":[0.0003412589,0.003441533,0.001946464,0.00001057154,0.00003253804,0.001480145,0.00003863221,0.002577219,0.9737327,0.0001603401,0.01621684,0.00002177499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783222,0.004166842,0.01026738,0.0002594911,0.00005591146,0.0001164597,0.0003571175,0.0002092634,0.006245406],"genre_scores_gemma":[0.9827655,0.002842161,0.009417253,0.0001534698,0.00002304152,0.00005353475,0.0005008101,0.00002568223,0.004218511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399966,"threshold_uncertainty_score":0.004683375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00974252970065202,"score_gpt":0.2364244497270833,"score_spread":0.2266819200264313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}