{"id":"W2952552052","doi":"10.1016/j.bmcl.2005.05.131","title":"2-Aminoquinazoline inhibitors of cyclin-dependent kinases","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Kinase; Chemistry; Cyclin-dependent kinase; Threonine; Serine; Protein-Serine-Threonine Kinases; Cyclin-dependent kinase 4; Cell cycle; Cell cycle checkpoint; Cyclin; Cancer research; CHEK1; Biochemistry; Phosphorylation; Cell biology; Cyclin-dependent kinase 2; Cell; Protein kinase A; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001874412,0.0003358547,0.0004238885,0.00004015179,0.00009916603,0.0000161476,0.0005098442,0.0001873326,0.004820595],"category_scores_gemma":[0.0001372502,0.0003172134,0.0001674383,0.0001854119,0.0002902641,0.00007464244,0.0001059675,0.0003352831,0.00009328069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660486,"about_ca_system_score_gemma":0.00008422814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004266119,"about_ca_topic_score_gemma":0.000003865365,"domain_scores_codex":[0.9977324,0.0000107395,0.000728433,0.0005080503,0.0005755095,0.0004448961],"domain_scores_gemma":[0.9985257,0.0001260018,0.0003509919,0.0006897387,0.00007471185,0.0002328727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002622033,0.0002351761,0.0006921655,0.0002202178,0.00004910605,0.00001368173,0.00009637194,0.000006628552,0.9895048,0.00001672395,0.003549107,0.005589833],"study_design_scores_gemma":[0.0006496959,0.00000754129,0.0003012292,0.0001475422,0.0001015097,0.00007047562,0.0002886106,0.00003134305,0.9834058,0.00001201393,0.01468109,0.0003031642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863434,0.0005705857,0.00008352025,0.007495033,0.00005912123,0.00007043532,0.00005597939,0.0001263065,0.005195648],"genre_scores_gemma":[0.9963174,0.00008587664,0.0003419492,0.0004841669,0.001981684,0.00002842041,0.0000662472,0.00005066035,0.0006435798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01113198,"threshold_uncertainty_score":0.999928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008536263674221296,"score_gpt":0.2221564652370524,"score_spread":0.2136202015628311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}