{"id":"W2952564762","doi":"10.1002/chin.200703193","title":"New Bioorganic Reagents: Evolved Cyclohexanone Monoxygenase — Why Is it more Selective?","year":2007,"lang":"en","type":"article","venue":"ChemInform","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"","keywords":"Chemistry; Cyclohexanone; Reagent; Bioorganic chemistry; Combinatorial chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007828556,0.0003988612,0.0004121267,0.0002334003,0.0002325835,0.000791035,0.0005100916,0.0006902049,0.00441156],"category_scores_gemma":[0.0007967994,0.000212739,0.0001899399,0.0002470187,0.0004213965,0.001173235,0.0003800974,0.001125357,0.001304612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005088363,"about_ca_system_score_gemma":0.0002835001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003036964,"about_ca_topic_score_gemma":0.0007599232,"domain_scores_codex":[0.9996454,0.00007005186,0.00002092044,0.00006187375,0.0001258434,0.00007590459],"domain_scores_gemma":[0.9997645,0.00008292306,0.00003276062,0.00002105793,0.00004970368,0.00004909811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004372007,0.0001319957,0.0005154749,0.0007074592,0.00006177425,0.0003548716,0.0001128835,0.000315594,0.9096228,0.01203855,0.00393709,0.07176425],"study_design_scores_gemma":[0.00005506317,0.0004808523,0.0005077292,0.00005979064,0.00005217897,0.000584948,0.00008627079,0.0004478985,0.9462569,0.001904454,0.04954101,0.00002284948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6452401,0.1661416,0.08116388,0.02446771,0.004533241,0.0003043258,0.0007789398,0.001746732,0.07562348],"genre_scores_gemma":[0.8957664,0.04255103,0.02229634,0.004529295,0.0004253259,0.0000922278,0.0004430402,0.0002281596,0.03366813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00441156,"threshold_uncertainty_score":0.01475811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106191511494034,"score_gpt":0.2546896083546925,"score_spread":0.2436276932397521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}