{"id":"W2952624599","doi":"10.1093/infdis/jiz306","title":"Single-Dose Mucosal Immunotherapy With Chimpanzee Adenovirus-Based Vaccine Accelerates Tuberculosis Disease Control and Limits Its Rebound After Antibiotic Cessation","year":2019,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Government of Ontario","keywords":"Medicine; Antibiotics; Immunotherapy; Immunology; Tuberculosis; Disease; Lung; Tuberculosis vaccines; Respiratory system; Immune system; Mycobacterium tuberculosis; Internal medicine; Biology; Pathology; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003031953,0.00040401,0.0004072892,0.0002392987,0.0001444688,0.0003285148,0.0002242829,0.0004602649,0.001308252],"category_scores_gemma":[0.0002978133,0.0001110842,0.0002625543,0.00009192014,0.0003823415,0.0003283059,0.0001540133,0.001152665,0.0002266737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002267323,"about_ca_system_score_gemma":0.0003530924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004572414,"about_ca_topic_score_gemma":0.0007410249,"domain_scores_codex":[0.9998314,0.00003089863,0.00001203133,0.00005161544,0.00002915102,0.00004479948],"domain_scores_gemma":[0.9997578,0.00005954178,0.00006475427,0.00003953528,0.00001867158,0.00005965318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006891796,0.0005880505,0.00095042,0.000130374,0.00001399009,0.00005984864,0.0000306742,0.0002350438,0.9879522,0.0001448495,0.0001189692,0.009086316],"study_design_scores_gemma":[0.0003461887,0.02107422,0.01069325,0.00005081178,0.00008074479,0.0009217991,0.0001007837,0.00270377,0.9602154,0.0001434288,0.003656732,0.00001294302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935971,0.002464474,0.002702233,0.0001644589,0.00007006713,0.00008367994,0.00006595619,0.000122938,0.0007289408],"genre_scores_gemma":[0.9954292,0.0008239271,0.002459994,0.00005947255,0.00002848171,0.00005357098,0.00008569456,0.00001410452,0.001045577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001308252,"threshold_uncertainty_score":0.00437659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221495962297411,"score_gpt":0.2725748359662032,"score_spread":0.2603598763432292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}