{"id":"W2952632749","doi":"10.1158/2159-8290.cd-19-0061","title":"Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling","year":2019,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Center for Advancing Translational Sciences; Children's Cancer Research Fund; National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Cancer Institute; National Institutes of Health; Bear Necessities Pediatric Cancer Foundation; Cancer Prevention and Research Institute of Texas; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Biology; Polyunsaturated fatty acid; Stem cell; Cancer research; Glioma; Cell biology; Downregulation and upregulation; Fatty acid; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001869172,0.0002486705,0.0001909105,0.0002075888,0.0001669996,0.0005784169,0.0001771854,0.0003902384,0.001721891],"category_scores_gemma":[0.000154147,0.0001207272,0.0001597478,0.0001769656,0.0003988939,0.0003501173,0.0004602587,0.001111255,0.0005216917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006814756,"about_ca_system_score_gemma":0.0003088609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005782121,"about_ca_topic_score_gemma":0.001924695,"domain_scores_codex":[0.9999006,0.00001191509,0.0000042761,0.00002112678,0.00003881631,0.00002327248],"domain_scores_gemma":[0.9999015,0.00001804245,0.00002153063,0.000009454681,0.00002793412,0.00002146809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003199983,0.00002707356,0.0006564423,0.0001615121,0.00001752691,0.000195121,0.00005258913,0.0002604025,0.9731266,0.003794723,0.004872993,0.01651506],"study_design_scores_gemma":[0.00005091419,0.0002902588,0.006470669,0.00005294693,0.00004427875,0.000484117,0.0001666891,0.001590723,0.8840591,0.002965725,0.1038044,0.00002022253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8537083,0.06591005,0.02610214,0.02227386,0.002406905,0.0001399747,0.002306044,0.00126332,0.02588957],"genre_scores_gemma":[0.9570066,0.02170772,0.004123372,0.002737688,0.0003086804,0.00005085523,0.000764444,0.0001251939,0.01317547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001721891,"threshold_uncertainty_score":0.005760312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204866861162243,"score_gpt":0.2389533652382087,"score_spread":0.2269046966265863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}