{"id":"W2952634658","doi":"10.1101/265462","title":"RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Agence Nationale de la Recherche; European Commission","keywords":"Tuberculosis; Secretion; Mycobacterium tuberculosis; Virulence; Epitope; Mycobacterium bovis; Antigen; Immune system; Tuberculosis vaccines; Biology; Microbiology; Virology; BCG vaccine; Vaccination; Immunology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001609601,0.0004045885,0.0002498895,0.0001704518,0.00009535343,0.0002556508,0.0003031395,0.0003508208,0.00203082],"category_scores_gemma":[0.0001887111,0.0001473885,0.0002986703,0.0001416269,0.0002112197,0.0001393571,0.0002569231,0.0009552666,0.0006587417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002029306,"about_ca_system_score_gemma":0.0001236027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004984888,"about_ca_topic_score_gemma":0.0003814955,"domain_scores_codex":[0.999691,0.00005969734,0.00005044222,0.00005877652,0.00007659152,0.0000635281],"domain_scores_gemma":[0.9997645,0.00004679995,0.00006839036,0.00004371531,0.00001859866,0.00005796409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009782253,0.00003614563,0.0001245942,0.00001899384,0.000003628674,0.00002806399,0.000007616236,0.00002632845,0.9992798,0.00002923254,0.00001709144,0.0003307981],"study_design_scores_gemma":[0.00001537119,0.0004540978,0.004584816,0.000007253581,0.00001324488,0.0002487955,0.00002615445,0.0007806029,0.9925281,0.00001968019,0.001317473,0.000004362993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967607,0.0003552166,0.001568829,0.00005983019,0.00003639257,0.00002005517,0.0004138401,0.00006201174,0.0007231142],"genre_scores_gemma":[0.9949828,0.0001301588,0.001029498,0.00004349627,0.000006180076,0.00002301669,0.001240639,0.00004585739,0.002498255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203082,"threshold_uncertainty_score":0.006793797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04705362943096408,"score_gpt":0.3197533243218679,"score_spread":0.2726996948909038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}