{"id":"W2952644065","doi":"10.1097/01.hs9.0000559996.44290.19","title":"PF446 EVALUATING EX VIVO EXPANSION OF FUNCTIONALLY COMPETENT MULTI-SPECIFIC T LYMPHOCYTES TO MINOR HISTOCOMPATIBILITY ANTIGEN FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Minor histocompatibility antigen; Immunology; CD8; T cell; Cytotoxic T cell; Stem cell; Priming (agriculture); Antigen; Haematopoiesis; Major histocompatibility complex; Biology; Cancer research; Immune system; Medicine; In vitro; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004197347,0.0001950084,0.0006236655,0.0000422478,0.00006858676,0.000007627176,0.0001360188,0.00008379301,0.006107644],"category_scores_gemma":[0.00007919504,0.0001174501,0.0003026061,0.0001658743,0.0001221453,0.00002677764,0.00004294539,0.00005053822,0.00004007742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003594439,"about_ca_system_score_gemma":0.0002151672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001158364,"about_ca_topic_score_gemma":0.00005214697,"domain_scores_codex":[0.9981492,0.00008278518,0.0005156767,0.0003909463,0.0005834717,0.0002779152],"domain_scores_gemma":[0.9978284,0.0008021671,0.0001551037,0.0006543075,0.0004614314,0.00009854352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002805491,0.001144344,0.0676157,0.0004019141,0.0001557843,0.000003560074,0.001483399,0.0002767827,0.9111224,0.0001450977,0.0006164766,0.01422901],"study_design_scores_gemma":[0.0117613,0.009480156,0.1805577,0.0004676213,0.0001313135,0.00004942284,0.004224439,0.009862926,0.7487285,0.00006034919,0.03436312,0.0003131792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909687,0.003175713,0.0009802328,0.0002027456,0.0002053836,0.004052801,0.00002986037,0.00002548548,0.000359082],"genre_scores_gemma":[0.9775025,0.0001844119,0.0131708,0.00005193617,0.00007443631,0.0002828482,0.00002020097,0.00002824389,0.008684652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1623939,"threshold_uncertainty_score":0.9948009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1249127160441747,"score_gpt":0.3660182318152017,"score_spread":0.241105515771027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}