{"id":"W2952644236","doi":"10.1038/s41416-019-0492-8","title":"Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers","year":2019,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; University of Toronto; Centre hospitalier universitaire de Québec; Hôpital du Saint-Sacrement; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Jonsson Comprehensive Cancer Center; National Center for Advancing Translational Sciences; European Regional Development Fund; Canadian Institutes of Health Research; lékařská fakulta Univerzity Karlovy; Manchester Biomedical Research Centre; University of California, San Francisco; National Institutes of Health; Kerry Group Kuok Foundation; Freistaat Sachsen; Centro de Investigación Biomédica en Red de Cáncer; Fox Chase Cancer Center; Ministero dello Sviluppo Economico; Medical Research Council; Uppsala Universitet; National Institute of General Medical Sciences; Institut National Du Cancer; Deutsche Krebshilfe; Sahlgrenska Universitetssjukhuset; Associazione Italiana per la Ricerca sul Cancro; Ovarian Cancer Research Fund; Ministerio de Economía y Competitividad; Landspítali Háskólasjúkrahús; Linköpings Universitet; Hungarian Scientific Research Fund; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Generalitat de Catalunya; Russian Foundation for Basic Research; Cancer Association of South Africa; Ministerstvo Školství, Mládeže a Tělovýchovy; National Breast Cancer Foundation; European Commission; National Institute for Health and Care Research; KWF Kankerbestrijding; Cancer Research UK; Government of Canada; National Cancer Institute; Liga Portuguesa Contra o Cancro; Hospital de Câncer de Barretos; NRG Oncology; Memorial Sloan-Kettering Cancer Center; Fondation du cancer du sein du Québec; Israel Cancer Association; Institut Català de la Salut; University of Pennsylvania; Fundación Mutua Madrileña; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Genome Canada; Breast Cancer Research Foundation; McGill University; Univerzita Karlova v Praze; Unicancer; Clalit Health Services; Deutsches Krebsforschungszentrum; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancer Center, University of Kansas; Cancerfonden; Ministério da Ciência, Tecnologia e Inovação; Dr. Ralph and Marian Falk Medical Research Trust; Kansas Bioscience Authority; Beth Israel Deaconess Medical Center; Alpha Omega Alpha Honor Medical Society; Georgetown University; Susan G. Komen for the Cure; Instituto de Salud Carlos III; Ohio State University; Cancer Australia; National Health and Medical Research Council; Jewish General Hospital; Fundación Cellex; Fisher Center for Alzheimer's Research Foundation; Istituto Oncologico Veneto; Umeå Universitet; Royal Marsden NHS Foundation Trust; European Social Fund; University of Chicago; Lietuvos Mokslo Taryba","keywords":"Ovarian cancer; Body mass index; Oncology; Medicine; Mendelian inheritance; Mutation; Internal medicine; Cancer; Genetics; Biology; Gynecology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01523366,0.001339335,0.001724886,0.001209994,0.000755891,0.0007377997,0.001514101,0.001358247,0.002487585],"category_scores_gemma":[0.03020475,0.001303604,0.00244821,0.001568515,0.0009656661,0.0005231071,0.0007313539,0.001226096,0.0003644978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008198735,"about_ca_system_score_gemma":0.000971714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007840421,"about_ca_topic_score_gemma":0.004299423,"domain_scores_codex":[0.9874524,0.009013765,0.0006260774,0.001654709,0.0007887901,0.0004641362],"domain_scores_gemma":[0.9876229,0.006197327,0.001736203,0.003567656,0.0004471974,0.0004287272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07782694,0.001601841,0.8555046,0.0005417613,0.01928368,0.003062116,0.001261313,0.004093551,0.006516002,0.003150278,0.002683433,0.02447448],"study_design_scores_gemma":[0.04157575,0.01968568,0.8299376,0.0001573338,0.01782301,0.005114745,0.0005212281,0.06720276,0.002906357,0.007531134,0.007240487,0.000303929],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832185,0.001006023,0.01341837,0.0001195393,0.00008809016,0.0009526821,0.0007076269,0.00008011282,0.0004089075],"genre_scores_gemma":[0.9893659,0.0002097408,0.00679691,0.0001573813,0.00004597689,0.001107807,0.001145329,0.00003694952,0.001134041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01523366,"threshold_uncertainty_score":0.0805642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007762646086976757,"score_gpt":0.2774016525593803,"score_spread":0.2696390064724035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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