{"id":"W2952644236","doi":"10.1038/s41416-019-0492-8","title":"Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers","year":2019,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; University of Toronto; Centre hospitalier universitaire de Québec; Hôpital du Saint-Sacrement; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Jonsson Comprehensive Cancer Center; National Center for Advancing Translational Sciences; European Regional Development Fund; Canadian Institutes of Health Research; lékařská fakulta Univerzity Karlovy; Manchester Biomedical Research Centre; University of California, San Francisco; National Institutes of Health; Kerry Group Kuok Foundation; Freistaat Sachsen; Centro de Investigación Biomédica en Red de Cáncer; Fox Chase Cancer Center; Ministero dello Sviluppo Economico; Medical Research Council; Uppsala Universitet; National Institute of General Medical Sciences; Institut National Du Cancer; Deutsche Krebshilfe; Sahlgrenska Universitetssjukhuset; Associazione Italiana per la Ricerca sul Cancro; Ovarian Cancer Research Fund; Ministerio de Economía y Competitividad; Landspítali Háskólasjúkrahús; Linköpings Universitet; Hungarian Scientific Research Fund; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Generalitat de Catalunya; Russian Foundation for Basic Research; Cancer Association of South Africa; Ministerstvo Školství, Mládeže a Tělovýchovy; National Breast Cancer Foundation; European Commission; National Institute for Health and Care Research; KWF Kankerbestrijding; Cancer Research UK; Government of Canada; National Cancer Institute; Liga Portuguesa Contra o Cancro; Hospital de Câncer de Barretos; NRG Oncology; Memorial Sloan-Kettering Cancer Center; Fondation du cancer du sein du Québec; Israel Cancer Association; Institut Català de la Salut; University of Pennsylvania; Fundación Mutua Madrileña; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Genome Canada; Breast Cancer Research Foundation; McGill University; Univerzita Karlova v Praze; Unicancer; Clalit Health Services; Deutsches Krebsforschungszentrum; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancer Center, University of Kansas; Cancerfonden; Ministério da Ciência, Tecnologia e Inovação; Dr. Ralph and Marian Falk Medical Research Trust; Kansas Bioscience Authority; Beth Israel Deaconess Medical Center; Alpha Omega Alpha Honor Medical Society; Georgetown University; Susan G. Komen for the Cure; Instituto de Salud Carlos III; Ohio State University; Cancer Australia; National Health and Medical Research Council; Jewish General Hospital; Fundación Cellex; Fisher Center for Alzheimer's Research Foundation; Istituto Oncologico Veneto; Umeå Universitet; Royal Marsden NHS Foundation Trust; European Social Fund; University of Chicago; Lietuvos Mokslo Taryba","keywords":"Ovarian cancer; Body mass index; Oncology; Medicine; Mendelian inheritance; Mutation; Internal medicine; Cancer; Genetics; Biology; Gynecology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004235075,0.0001281167,0.0006172234,0.0002001939,0.00003297811,0.00002527735,0.00004881557,0.00008017864,0.0002342315],"category_scores_gemma":[0.00005141691,0.0001252215,0.00006786621,0.0001803567,0.00005766879,0.0001830612,0.00001269276,0.0002111597,2.105453e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000253733,"about_ca_system_score_gemma":0.0003346122,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02537374,"about_ca_topic_score_gemma":0.003815799,"domain_scores_codex":[0.9984981,0.0001112245,0.000633547,0.0002024102,0.000405426,0.00014933],"domain_scores_gemma":[0.9987822,0.00006726259,0.0006494035,0.0001042122,0.0002617738,0.0001351857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00228407,0.0003262318,0.9120464,0.0001394654,0.0008631739,0.0001796286,0.001939436,0.001086494,0.0006307148,0.00001331818,0.000102608,0.0803884],"study_design_scores_gemma":[0.04574571,0.001023256,0.9467313,0.00106667,0.0005953616,0.0001775936,0.002594638,0.0003979028,0.001181485,0.0001844693,0.0001848771,0.0001167874],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864959,0.01197079,0.00002407936,0.0002653511,0.0002531873,0.0007187641,0.00005257149,0.000002635416,0.0002166843],"genre_scores_gemma":[0.9859434,0.01372303,0.00007950977,0.00005511895,0.00008733411,0.00003736735,0.00000246249,0.00001823794,0.00005352699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08027161,"threshold_uncertainty_score":0.9811164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007762646086976757,"score_gpt":0.2774016525593803,"score_spread":0.2696390064724035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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