{"id":"W2952693279","doi":"10.1139/v99-240","title":"A new short synthetic approach to chlorocyclopentenones related to cryptosporiopsin via a ring expansion strategy: first synthesis of a fungitoxic metabolite from <i>Sporormia affinis</i>","year":2000,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Cycloaddition; Stereochemistry; Metabolite; Cyclopentene; Ring (chemistry); Yield (engineering); Total synthesis; Claisen rearrangement; Organic chemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117323,0.0005231742,0.0002197253,0.0001796042,0.0001763955,0.0001488957,0.0002692077,0.0002704665,0.001729983],"category_scores_gemma":[0.00008785977,0.0001347001,0.0002454972,0.0001644481,0.0001747867,0.0002582276,0.0002749471,0.000495569,0.0005001625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002038489,"about_ca_system_score_gemma":0.0004641752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003838485,"about_ca_topic_score_gemma":0.0009928175,"domain_scores_codex":[0.9999304,0.000009713895,0.000008081291,0.00001675318,0.00001352897,0.00002162156],"domain_scores_gemma":[0.9999363,0.000008725096,0.00001434543,0.000008762412,0.00001042237,0.00002145832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009877313,0.00005666895,0.0001235974,0.0001678014,0.000009618523,0.0003517628,0.00004813611,0.0003215423,0.9867392,0.000543237,0.0001455267,0.01139416],"study_design_scores_gemma":[0.00005453135,0.001610551,0.001098588,0.000009745403,0.00002291552,0.0009665177,0.00003764093,0.0002886693,0.9826913,0.0001653673,0.01303753,0.00001661148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8812472,0.007680013,0.08455245,0.000488601,0.0003993524,0.000735467,0.001276343,0.0005530764,0.02306754],"genre_scores_gemma":[0.9491569,0.004708809,0.03871055,0.0001557577,0.00005622479,0.0001682232,0.0007860948,0.00003860781,0.006218759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001729983,"threshold_uncertainty_score":0.005787432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123622930864417,"score_gpt":0.2387652872443478,"score_spread":0.2275290579357036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}