{"id":"W2952770983","doi":"10.1161/res.119.suppl_1.80","title":"Abstract 80: PI3Kα Regulates Biomechanical Stress-induced Cytoskeletal Remodeling: A Critical Role of Gelsolin","year":2016,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"","keywords":"Gelsolin; Pressure overload; Cytoskeleton; Cell biology; Actin cytoskeleton; PI3K/AKT/mTOR pathway; Mechanotransduction; Biology; Internal medicine; Endocrinology; Heart failure; Actin remodeling; Ventricular remodeling; Actin; Medicine; Signal transduction; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006538517,0.0001189951,0.0001437563,0.0001740246,0.0001310246,0.00003487027,0.0002229395,0.000240364,0.0002890891],"category_scores_gemma":[0.0009002504,0.00009746459,0.0001382891,0.000181341,0.00009943524,0.00001573693,0.0001471593,0.0001740574,0.00005406389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003835967,"about_ca_system_score_gemma":0.0001310571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006045891,"about_ca_topic_score_gemma":0.0000191398,"domain_scores_codex":[0.9983024,0.000118893,0.0003496098,0.0004241022,0.0004367062,0.0003682912],"domain_scores_gemma":[0.9985468,0.0001226822,0.00005922569,0.0004944878,0.0006305736,0.00014626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005396395,0.00012688,0.0002030172,0.00001874123,0.00002483514,0.000001588122,0.00001518141,0.00003857378,0.9885508,0.004672487,0.00009016399,0.006203783],"study_design_scores_gemma":[0.0003484916,0.0001835271,0.002023153,0.00007271295,0.000007341126,0.00001037821,0.000107043,0.007335169,0.98303,0.005407573,0.001322567,0.0001520801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931026,0.0002393115,0.004788277,0.0005276618,0.0001155044,0.0001848091,0.00004216079,0.00001404333,0.0009856891],"genre_scores_gemma":[0.9992967,0.0000605995,0.0002092338,0.0000107143,0.0001976986,0.00001883852,0.00006593706,0.00002726317,0.0001130737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007296596,"threshold_uncertainty_score":0.397449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06017756802142789,"score_gpt":0.3742285072288934,"score_spread":0.3140509392074656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}