{"id":"W2952791416","doi":"10.1002/chin.200343132","title":"High Throughput Screening Identifies Novel Inhibitors of Escherichia coli Dihydrofolate Reductase that Are Competitive with Dihydrofolate.","year":2003,"lang":"en","type":"article","venue":"ChemInform","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Dihydrofolate reductase; Chemistry; Escherichia coli; Throughput; Biochemistry; Combinatorial chemistry; Enzyme; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001969214,0.0003008524,0.0003196727,0.00005036783,0.0001110739,0.00004324698,0.0002713155,0.0002560964,0.0000505795],"category_scores_gemma":[0.000118093,0.000251798,0.0001449905,0.0002321782,0.0003867658,0.0000188775,0.0001993915,0.000243282,0.000006865075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002251006,"about_ca_system_score_gemma":0.0001008583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005207297,"about_ca_topic_score_gemma":0.0000147332,"domain_scores_codex":[0.9984066,0.00000459247,0.000308389,0.0004451532,0.0003659379,0.0004693235],"domain_scores_gemma":[0.9988939,0.00001765475,0.0002376144,0.0004753128,0.0001955872,0.0001799972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001941978,0.0001095998,0.0005814793,0.00009664866,0.0001644284,0.000008349642,0.0000792214,0.00000629529,0.99653,0.0004192837,0.001295482,0.0005149946],"study_design_scores_gemma":[0.001150802,0.0001699398,0.0002926563,0.0001267003,0.00003517159,0.0000229062,0.0006017437,0.000005517071,0.9837769,0.00003758648,0.01344206,0.0003379583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777653,0.0006119129,0.0002954978,0.00009230779,0.00009419713,0.0003036967,0.00006489464,0.00002217546,0.02075006],"genre_scores_gemma":[0.9957753,0.0001100086,0.001166775,0.0001277927,0.00008186053,0.00003348954,0.0002472165,0.00004269723,0.002414844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01833522,"threshold_uncertainty_score":0.9999934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464825289255024,"score_gpt":0.2412378573778566,"score_spread":0.2265896044853064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}