{"id":"W2952791416","doi":"10.1002/chin.200343132","title":"High Throughput Screening Identifies Novel Inhibitors of Escherichia coli Dihydrofolate Reductase that Are Competitive with Dihydrofolate.","year":2003,"lang":"en","type":"article","venue":"ChemInform","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Dihydrofolate reductase; Chemistry; Escherichia coli; Throughput; Biochemistry; Combinatorial chemistry; Enzyme; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003868319,0.0009286241,0.0008783905,0.0005221984,0.0003429421,0.0008014903,0.0007128878,0.0007390991,0.002867617],"category_scores_gemma":[0.0003559483,0.0003240902,0.0004589127,0.0004669446,0.000212942,0.0002805718,0.0002887867,0.0007216436,0.00183181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008518773,"about_ca_system_score_gemma":0.0004332016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006659,"about_ca_topic_score_gemma":0.003876589,"domain_scores_codex":[0.9996696,0.00004608157,0.00001512404,0.00004806678,0.0001493419,0.00007190014],"domain_scores_gemma":[0.9998487,0.00005074355,0.00002456294,0.00001466966,0.00003193304,0.00002929941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008683708,0.0007102406,0.001180973,0.0002086123,0.0001074653,0.0002948429,0.00001808849,0.000950406,0.9672902,0.0003519163,0.002467988,0.02555077],"study_design_scores_gemma":[0.0002939855,0.002355804,0.004225435,0.00002155759,0.0002437526,0.001550513,0.00002787637,0.005081555,0.9708772,0.0001708541,0.01511757,0.00003398796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9230742,0.02204284,0.02916126,0.00142488,0.000263093,0.0007109733,0.005808302,0.00164429,0.01587013],"genre_scores_gemma":[0.9575454,0.007859092,0.01347461,0.000544176,0.00006664132,0.0002338334,0.007958553,0.00007995037,0.01223777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002867617,"threshold_uncertainty_score":0.009593129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464825289255024,"score_gpt":0.2412378573778566,"score_spread":0.2265896044853064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}