{"id":"W2952813149","doi":"10.1021/ol900070x","title":"Sc(OTf)<sub>3</sub>-Catalyzed Direct Alkylation of Quinolines and Pyridines with Alkanes","year":2009,"lang":"en","type":"article","venue":"Organic Letters","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Alkylation; Chemistry; Catalysis; Peroxide; Medicinal chemistry; Organic chemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273072,0.0004412163,0.0001799122,0.0001348285,0.0001350709,0.000114185,0.0002829004,0.0002145937,0.001091137],"category_scores_gemma":[0.0001597134,0.0001145054,0.0002105305,0.0001522656,0.0002398565,0.0002379445,0.0002373271,0.0003193016,0.0003817746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002027682,"about_ca_system_score_gemma":0.0002310661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009957,"about_ca_topic_score_gemma":0.002396217,"domain_scores_codex":[0.9999051,0.00000850967,0.000005752469,0.0000184741,0.00002767161,0.00003452914],"domain_scores_gemma":[0.9999151,0.00001682762,0.00002503328,0.00000996646,0.00002019191,0.00001295173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003734957,0.000007853514,0.0001441417,0.00008841137,0.00000685606,0.0001182406,0.00002792716,0.0001008748,0.9949768,0.000159133,0.00005649053,0.004275809],"study_design_scores_gemma":[0.000002691567,0.0000758373,0.0004683938,0.000002075553,0.000004328967,0.0001327576,0.000007328142,0.0002073987,0.9980918,0.00001909518,0.0009848429,0.000003388587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621563,0.003731282,0.02675685,0.00008140497,0.0000524605,0.0001141097,0.0002425897,0.0002171166,0.006647883],"genre_scores_gemma":[0.9889432,0.001277933,0.007604595,0.00002359943,0.000007814261,0.00002647123,0.0001452494,0.00001641006,0.00195478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001091137,"threshold_uncertainty_score":0.003650188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009404250082178574,"score_gpt":0.2236543726399403,"score_spread":0.2142501225577617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}