{"id":"W2952817796","doi":"10.1097/01.hs9.0000560592.99613.ac","title":"PF576 NONSENSE‐MEDIATED MRNA DECAY IS A THERAPEUTIC TARGET IN MULTIPLE MYELOMA","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Nonsense-mediated decay; Gene knockdown; RNA splicing; Cell culture; Biology; Molecular biology; Cancer cell; Translation (biology); Cancer research; Cancer; Messenger RNA; Cell biology; Chemistry; Gene; RNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003755254,0.0004489303,0.0004239917,0.0004601489,0.0002379309,0.0004991821,0.0003608854,0.0005377733,0.002206882],"category_scores_gemma":[0.0001906531,0.0001098495,0.0003143879,0.0004741927,0.0003022092,0.0002502287,0.000258835,0.0009550469,0.0005245924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008061981,"about_ca_system_score_gemma":0.0003872516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000605258,"about_ca_topic_score_gemma":0.0007938024,"domain_scores_codex":[0.9997991,0.00002152723,0.00001539319,0.00003542413,0.00008498262,0.00004367177],"domain_scores_gemma":[0.9999013,0.00001809226,0.00003086874,0.00001287478,0.00001458026,0.00002236552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001496622,0.0004571511,0.001163355,0.000363326,0.00004904482,0.0003552641,0.00003665735,0.0007796737,0.9353272,0.0009994934,0.001661828,0.05731037],"study_design_scores_gemma":[0.00035745,0.004266581,0.005608904,0.00005580702,0.0001199659,0.002053533,0.00002990464,0.002092489,0.9571585,0.0003292129,0.02791456,0.00001313545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9298561,0.04019247,0.0109194,0.001961446,0.0003148874,0.0003252683,0.001300718,0.0009633545,0.01416624],"genre_scores_gemma":[0.9851701,0.006206635,0.004243798,0.0002496151,0.00004362373,0.0001012288,0.001231075,0.00003947339,0.002714494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002206882,"threshold_uncertainty_score":0.00738281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317766469733666,"score_gpt":0.2553419357255027,"score_spread":0.242164271028166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}