{"id":"W2952829067","doi":"10.2174/1389201020666190613152030","title":"Comprehensive in silico Study of GLUT10: Prediction of Possible Substrate Binding Sites and Interacting Molecules","year":2020,"lang":"en","type":"article","venue":"Current Pharmaceutical Biotechnology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Virtual screening; Homology modeling; In silico; Binding site; Docking (animal); Metabolite; Computational biology; Chemistry; Biology; Biochemistry; Gene; Genetics; Medicine; Enzyme; Drug discovery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008408498,0.0001239803,0.0002224296,0.0001503292,0.0000248542,0.000005864494,0.0001668202,0.0001356612,0.00001183324],"category_scores_gemma":[0.0002448137,0.0001278489,0.00003184232,0.0003270083,0.0002209894,0.000005951724,0.0003208242,0.0003280409,0.000001600663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009437364,"about_ca_system_score_gemma":0.00002301539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009337856,"about_ca_topic_score_gemma":0.000009538844,"domain_scores_codex":[0.9989165,0.0001054242,0.0003000303,0.0003661917,0.0001057654,0.0002060527],"domain_scores_gemma":[0.9995815,0.00005489731,0.00008593891,0.0001308323,0.00008349447,0.00006332685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002163117,0.0003628934,0.07797093,0.0001416066,0.00004640159,0.000003483067,0.0002403271,0.0000324844,0.9046233,0.00004881131,0.00001200407,0.0163014],"study_design_scores_gemma":[0.001709092,0.001160055,0.00967887,0.00003274393,0.00002083894,0.000004746295,0.002441777,0.004228418,0.9798319,0.00001717829,0.0007692497,0.000105128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955425,0.003409883,0.0001577371,0.0003776759,0.00004465193,0.000403265,0.00003142448,0.0000162547,0.00001666785],"genre_scores_gemma":[0.99917,0.0007023672,0.00004677074,0.00001171587,0.00001775341,0.00001345159,0.00002683748,0.00001021324,8.825278e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07520856,"threshold_uncertainty_score":0.5213528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1044289255441374,"score_gpt":0.3909482428785918,"score_spread":0.2865193173344545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}