{"id":"W2952831623","doi":"10.7554/elife.40092","title":"CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks","year":2019,"lang":"en","type":"article","venue":"eLife","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; SickKids Foundation; University of Toronto; McMaster University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Hospital for Sick Children; Canada Foundation for Innovation; Ontario Brain Institute; Canadian Institute for Advanced Research; Autism Speaks; Canadian Institutes of Health Research; Genome Canada; National Human Genome Research Institute; McLaughlin Centre, University of Toronto","keywords":"Induced pluripotent stem cell; Reprogramming; Autism spectrum disorder; Neuroscience; Autism; Polygenic risk score; Biology; Psychology; Genetics; Gene; Psychiatry; Single-nucleotide polymorphism; Genotype; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001219427,0.0003070146,0.0003078604,0.0005168727,0.0004732217,0.0009489224,0.000416732,0.000821517,0.009445302],"category_scores_gemma":[0.001938987,0.0001809087,0.0002930502,0.0002400395,0.000497607,0.0005064073,0.0003748176,0.001284908,0.003966463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000263944,"about_ca_system_score_gemma":0.0002690489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002281203,"about_ca_topic_score_gemma":0.0005027904,"domain_scores_codex":[0.9991622,0.0001107671,0.0001211625,0.0001391712,0.0004169743,0.00004976578],"domain_scores_gemma":[0.9983986,0.0004735999,0.0002176103,0.0001269864,0.0006252285,0.0001580721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007530635,0.00008716137,0.006990975,0.0008670753,0.00008450717,0.004071048,0.0004077387,0.0002933834,0.5833035,0.003649413,0.2885953,0.1108969],"study_design_scores_gemma":[0.0000725363,0.0002000173,0.01096025,0.0001434739,0.00009971659,0.005486309,0.0003269904,0.001331253,0.3137475,0.001757964,0.6658262,0.00004777077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3718971,0.02695884,0.09632162,0.06320557,0.3238106,0.0006442387,0.01022869,0.00539987,0.1015335],"genre_scores_gemma":[0.657836,0.02763616,0.04621359,0.02411305,0.04752508,0.0005085866,0.008358912,0.003109713,0.1846989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009445302,"threshold_uncertainty_score":0.03159773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03666581769336093,"score_gpt":0.2942198744850877,"score_spread":0.2575540567917268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}