{"id":"W2952842332","doi":"10.1016/j.celrep.2018.11.056","title":"Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Bank of America; National Human Genome Research Institute; Canadian Institutes of Health Research; Frontiers Foundation; Charles A. King Trust; Simeon J. Fortin Charitable Foundation; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; California Institute of Technology; Broad Institute; Raymond and Beverly Sackler Foundation","keywords":"Haematopoiesis; Myeloid; Stem cell; Biology; Immunology; Hematopoietic stem cell; Inflammation; Population; Immune system; Cancer research; Cell biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001864384,0.0001701353,0.0002287567,0.0003626677,0.0001761172,0.000339873,0.0001177264,0.0001553028,0.0006655313],"category_scores_gemma":[0.0001675246,0.0001222151,0.0001786305,0.000282238,0.0002349917,0.0002226472,0.0002463275,0.000266503,0.0002396016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663416,"about_ca_system_score_gemma":0.0001301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003879934,"about_ca_topic_score_gemma":0.000801844,"domain_scores_codex":[0.9998547,0.00001369033,0.00001184939,0.00005340292,0.00004225797,0.00002405776],"domain_scores_gemma":[0.9998735,0.00001633404,0.00004677819,0.00001332149,0.00002496331,0.00002522166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008289859,0.000005205401,0.005542381,0.00002205709,0.000009843706,0.00004997549,0.00006345149,0.00004522796,0.9906982,0.00008623165,0.00004725582,0.003347267],"study_design_scores_gemma":[0.00001133302,0.0002440753,0.4555476,0.00001944215,0.00007533991,0.0005826842,0.0002910191,0.0008441739,0.5360959,0.0004879213,0.005781525,0.00001902836],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885929,0.002666149,0.006003058,0.00006019132,0.00002356692,0.00002404061,0.00139764,0.0000810758,0.001151369],"genre_scores_gemma":[0.9933987,0.001153291,0.002445867,0.0001031124,0.00001973982,0.00003721715,0.001140401,0.00003167313,0.001669997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006655313,"threshold_uncertainty_score":0.002226472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720208351716879,"score_gpt":0.23187012206875,"score_spread":0.2146680385515813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}