{"id":"W2952842332","doi":"10.1016/j.celrep.2018.11.056","title":"Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Bank of America; National Human Genome Research Institute; Canadian Institutes of Health Research; Frontiers Foundation; Charles A. King Trust; Simeon J. Fortin Charitable Foundation; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; California Institute of Technology; Broad Institute; Raymond and Beverly Sackler Foundation","keywords":"Haematopoiesis; Myeloid; Stem cell; Biology; Immunology; Hematopoietic stem cell; Inflammation; Population; Immune system; Cancer research; Cell biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001728168,0.0001894829,0.0002314757,0.00005148417,0.00005853893,0.00001927213,0.0001266134,0.0001235449,0.00001943738],"category_scores_gemma":[0.00001391296,0.0001661033,0.00008248653,0.00007449356,0.0001531196,0.000002593807,0.00006059243,0.00005596588,0.000009660321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001201315,"about_ca_system_score_gemma":0.00008984258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000126446,"about_ca_topic_score_gemma":0.00005796461,"domain_scores_codex":[0.9987212,0.00005709097,0.0003814438,0.0004226989,0.000173629,0.0002439839],"domain_scores_gemma":[0.9987985,0.00001371618,0.0002370723,0.000651218,0.0001510147,0.0001484472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003789933,0.00008660075,0.005384518,0.00008659426,0.00002944062,0.0005127746,0.0002215558,0.0001569896,0.9922446,6.175057e-7,0.0006590589,0.0002382636],"study_design_scores_gemma":[0.0002313218,0.0006861842,0.0005207473,0.00005313168,0.00002377293,0.0001868139,0.00005692411,0.000008097019,0.9858693,0.000007590304,0.01214443,0.000211724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973189,0.0002176221,0.001170022,0.00001396747,0.0003282034,0.0002568389,0.000008570494,0.00001953226,0.0006663632],"genre_scores_gemma":[0.9971011,0.00001475197,0.0005485789,0.0001506309,0.0001868194,0.00001220536,0.00001051937,0.00004053133,0.001934911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01148537,"threshold_uncertainty_score":0.6773494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720208351716879,"score_gpt":0.23187012206875,"score_spread":0.2146680385515813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}