{"id":"W2952843064","doi":"10.1021/jo001292p","title":"Asymmetric Baeyer−Villiger Oxidations of 4-Mono- and 4,4-Disubstituted Cyclohexanones by Whole Cells of Engineered<i>Escherichia</i><i>c</i><i>oli</i>","year":2001,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; University of New Brunswick","funders":"","keywords":"Escherichia coli; Enzyme; Chemistry; Cyclohexanone; Yeast; Strain (injury); Monooxygenase; Stereochemistry; Reagent; Monoclinic crystal system; Substrate (aquarium); Enantiomeric excess; Organic chemistry; Enantioselective synthesis; Crystal structure; Biochemistry; Catalysis; Biology; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001604346,0.0005281435,0.0002572011,0.0001116596,0.00008890908,0.0002158253,0.0001979415,0.0001854468,0.0006149506],"category_scores_gemma":[0.0001202754,0.000131356,0.0002201724,0.0001868066,0.0001070865,0.0002091619,0.0001912749,0.0005557593,0.0002566105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002288817,"about_ca_system_score_gemma":0.0002032971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007522441,"about_ca_topic_score_gemma":0.001307605,"domain_scores_codex":[0.9998873,0.00001604187,0.00001096457,0.00002468014,0.00002591081,0.00003505799],"domain_scores_gemma":[0.9999472,0.00001153465,0.0000157746,0.000007550871,0.000008505265,0.000009506823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003545279,0.00001302821,0.00008166895,0.00001981169,0.000003710742,0.00002394541,0.00001053225,0.00004564032,0.9986443,0.00008122613,0.00001553225,0.001025218],"study_design_scores_gemma":[0.000003041979,0.00004862352,0.0003493684,0.000001279197,0.000003448093,0.00002868377,0.000008887505,0.0001813904,0.9989448,0.000012905,0.0004158056,0.000001737087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903015,0.0005839352,0.00702617,0.00005273704,0.00003488865,0.00003055981,0.0002570552,0.00005339707,0.001659838],"genre_scores_gemma":[0.9842445,0.001092411,0.009850238,0.00002933202,0.00000729842,0.00003334071,0.0009882441,0.00004124125,0.003713364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007522441,"threshold_uncertainty_score":0.002057195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004032398356402414,"score_gpt":0.1972734005150917,"score_spread":0.1932410021586893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}