{"id":"W2952843064","doi":"10.1021/jo001292p","title":"Asymmetric Baeyer−Villiger Oxidations of 4-Mono- and 4,4-Disubstituted Cyclohexanones by Whole Cells of Engineered<i>Escherichia</i><i>c</i><i>oli</i>","year":2001,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; University of New Brunswick","funders":"","keywords":"Escherichia coli; Enzyme; Chemistry; Cyclohexanone; Yeast; Strain (injury); Monooxygenase; Stereochemistry; Reagent; Monoclinic crystal system; Substrate (aquarium); Enantiomeric excess; Organic chemistry; Enantioselective synthesis; Crystal structure; Biochemistry; Catalysis; Biology; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002754911,0.0001364425,0.0002470561,0.0000277262,0.00003676235,0.000009148556,0.0002613831,0.0001198847,0.00006647276],"category_scores_gemma":[0.0001606779,0.0001044031,0.00009230015,0.0003765706,0.00009794923,0.00001276437,0.00006289609,0.0001232988,7.896248e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009150198,"about_ca_system_score_gemma":0.00007642207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003837769,"about_ca_topic_score_gemma":0.000001053992,"domain_scores_codex":[0.999061,0.00003105086,0.0004976797,0.0001153901,0.0001696468,0.000125169],"domain_scores_gemma":[0.9988846,0.00003862491,0.0004827539,0.0002524793,0.0002608504,0.00008068318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004654317,0.00008515878,0.0003917309,0.00005098452,0.00009975153,5.707299e-7,0.0000533467,0.0001630159,0.9961571,6.007844e-7,0.002803168,0.0001480744],"study_design_scores_gemma":[0.0004448373,0.00008179909,0.0002157367,0.00002204089,0.0001329114,0.00004821076,0.000142409,0.00002883361,0.991168,0.000004067762,0.007608239,0.0001029367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870359,0.005898804,0.006499696,0.0001518152,0.0000392271,0.00005428629,0.00002687569,0.000002831694,0.0002905091],"genre_scores_gemma":[0.9952213,0.003999495,0.000241053,0.00007769698,0.0001111172,6.699256e-7,0.00004847434,0.00001915902,0.0002810917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008185287,"threshold_uncertainty_score":0.4257435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004032398356402414,"score_gpt":0.1972734005150917,"score_spread":0.1932410021586893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}