{"id":"W2952873921","doi":"10.1101/257485","title":"Structural and histone binding studies of the chromo barrel domain of TIP60","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Biological and Environmental Research; National Natural Science Foundation of China; University of Chicago; Pfizer; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Argonne National Laboratory; U.S. Department of Energy","keywords":"Isothermal titration calorimetry; Histone acetyltransferase; Chemistry; Histone; Acetylation; Biophysics; Biochemistry; Biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006026742,0.0003409963,0.0006072266,0.0001290498,0.0001979086,0.00004193729,0.0004555521,0.000276338,0.00006117314],"category_scores_gemma":[0.0002347734,0.0002484083,0.0001051755,0.0002575943,0.0008389144,0.0001102186,0.0007427813,0.0002801451,0.000006105011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001419216,"about_ca_system_score_gemma":0.0002338139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004673989,"about_ca_topic_score_gemma":0.000005494971,"domain_scores_codex":[0.9980943,0.0001448434,0.0005414273,0.0005669701,0.0003671446,0.0002853356],"domain_scores_gemma":[0.9977628,0.00006637809,0.0007595604,0.0008882698,0.0004484364,0.00007456357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002408954,0.00000845354,0.003096089,0.000560506,0.0000700747,0.000001837782,0.00008653624,0.000008853741,0.995408,0.0004415974,0.0002934803,5.128272e-7],"study_design_scores_gemma":[0.0002668735,0.00005608431,0.0586367,0.0004384879,0.0001071149,3.811794e-8,0.00002012317,0.00001722847,0.939923,0.00003912412,0.0002236542,0.0002715146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935583,0.0022277,0.000058685,0.00005813266,0.003492981,0.0003371324,0.0001946637,0.00006281339,0.000009524339],"genre_scores_gemma":[0.9961736,0.00009541027,0.003265167,0.00002795735,0.0003720523,0.00001978388,8.221704e-8,0.00004009464,0.000005804393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05554061,"threshold_uncertainty_score":0.9999968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01839259437702639,"score_gpt":0.2477945208835406,"score_spread":0.2294019265065142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}