{"id":"W2952898251","doi":"10.1038/s41531-019-0076-6","title":"Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability","year":2019,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; UK Dementia Research Institute; Rosetrees Trust; Parkinson's UK; National Institutes of Health; Medical Research Council; Barts Charity","keywords":"Cell type; Biology; Microglia; Parkinson's disease; Neuroscience; Gene; Heritability; Genetics; Cell; Disease; Pathology; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009763039,0.00027872,0.0004693969,0.0007936379,0.0002405094,0.0007706037,0.0001806677,0.0002142596,0.001042177],"category_scores_gemma":[0.002699818,0.0001139627,0.000382646,0.0007280806,0.000516944,0.0003399409,0.0005843961,0.0004310306,0.0001641566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000141626,"about_ca_system_score_gemma":0.0002374554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002042626,"about_ca_topic_score_gemma":0.002376836,"domain_scores_codex":[0.9991146,0.0002494918,0.00003671641,0.0004101159,0.0001129335,0.00007624354],"domain_scores_gemma":[0.998817,0.000670533,0.0001659924,0.0002105556,0.00007121983,0.00006480955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007638089,0.00005535554,0.6930447,0.0002259252,0.001319405,0.001246578,0.001340555,0.004203395,0.1849592,0.004479766,0.000858303,0.107503],"study_design_scores_gemma":[0.00000995374,0.00007413443,0.9810407,0.00003182694,0.0003038271,0.0005466192,0.0002521218,0.005857342,0.005154828,0.004560015,0.002144953,0.00002358672],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701141,0.001893191,0.02574263,0.0001498894,0.00002574034,0.00001180436,0.0007332878,0.0001005499,0.001228808],"genre_scores_gemma":[0.9963111,0.0002463319,0.002639188,0.00006633261,0.000012752,0.000007745891,0.0003470678,0.00004760625,0.0003219046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002042626,"threshold_uncertainty_score":0.005163252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01230852869075154,"score_gpt":0.2333981334704918,"score_spread":0.2210896047797403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}