{"id":"W2952913340","doi":"10.1097/01.hs9.0000562668.33884.40","title":"PS1094 MANAGING CYTOKINE RELEASE SYNDROME (CRS) AND NEUROTOXICITY WITH STEP‐FRACTIONATED DOSING OF MOSUNETUZUMAB IN RELAPSED/REFRACTORY (R/R) B‐CELL NON‐HODGKIN LYMPHOMA (NHL)","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"CNS Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Medicine; Cytokine release syndrome; Adverse effect; Dosing; Gastroenterology; Internal medicine; Chills; Refractory (planetary science); Immunotherapy; Cancer; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001239183,0.0003395163,0.0006698713,0.0001614978,0.00005840337,0.00002303252,0.0000818177,0.0001496477,0.000413795],"category_scores_gemma":[0.00002136618,0.0002834957,0.00009378027,0.0004225979,0.00007683806,0.0001572363,0.00006959545,0.0001838364,0.00005606824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003511644,"about_ca_system_score_gemma":0.0001710134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009992333,"about_ca_topic_score_gemma":0.000133555,"domain_scores_codex":[0.9981294,0.00005893267,0.0004627667,0.0005790276,0.0003988255,0.0003710446],"domain_scores_gemma":[0.9987735,0.0001644555,0.0002540622,0.000537295,0.00008097369,0.0001896711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004716283,0.005957468,0.8791013,0.002350371,0.0004089927,0.006156399,0.0005631032,0.0006716524,0.03884581,0.0001257472,0.0008135019,0.06028939],"study_design_scores_gemma":[0.02263027,0.003110269,0.9413946,0.00184074,0.0002685013,0.001520712,0.0006624179,0.005608421,0.02094623,0.00003374877,0.001489623,0.000494508],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928072,0.000972228,0.00002543442,0.0001937247,0.00008421682,0.001095443,0.00001549683,0.00006181909,0.004744454],"genre_scores_gemma":[0.9976875,0.000229921,0.0008972697,0.0001889174,0.00002199421,0.00006240211,0.0000310849,0.00007139191,0.0008095762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06229329,"threshold_uncertainty_score":0.9999617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006455756891176972,"score_gpt":0.2172970572834731,"score_spread":0.2108413003922962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}