{"id":"W2952949941","doi":"10.1016/j.bbi.2019.06.016","title":"Probiotic consumption during puberty mitigates LPS-induced immune responses and protects against stress-induced depression- and anxiety-like behaviors in adulthood in a sex-specific manner","year":2019,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Brain Institute; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Sickness behavior; Lipopolysaccharide; Endocrinology; Internal medicine; Hypothalamus; Probiotic; Immune system; Cytokine; Anxiety; Gut flora; Microbiome; Amygdala; Inflammation; Gut–brain axis; Medicine; Immunology; Biology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004784884,0.000293404,0.0003230577,0.0001816144,0.0001925409,0.00008261212,0.0001278353,0.0003540427,0.000009980802],"category_scores_gemma":[0.00004764774,0.0002816403,0.00004160623,0.0001174088,0.0001010954,0.00003648638,0.0002550764,0.0004591488,0.000002129431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003845577,"about_ca_system_score_gemma":0.00006575754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003705906,"about_ca_topic_score_gemma":0.0003744218,"domain_scores_codex":[0.9981081,0.0004027251,0.0003961915,0.0005764436,0.00009115203,0.0004253644],"domain_scores_gemma":[0.9992552,0.00003826114,0.000114102,0.0004253225,0.00004279027,0.0001242918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000176905,0.000161001,0.386141,0.0001157053,0.000003927708,0.000007459575,0.0004085964,2.299379e-7,0.6099713,7.550154e-7,0.000002474153,0.003010587],"study_design_scores_gemma":[0.001832281,0.0001582191,0.6886126,0.0002086078,0.000007564201,0.00005693952,0.0006096861,0.000003022421,0.3082357,0.00000146066,0.00003226729,0.0002415928],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966462,0.001671668,3.67427e-7,0.00006769255,0.00007453805,0.001471675,0.0000399177,0.00001790881,0.00001000446],"genre_scores_gemma":[0.9981669,0.001275558,0.00007023292,0.00005746373,0.00001579758,0.0001290447,0.0001310623,0.00003333857,0.0001206536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3024716,"threshold_uncertainty_score":0.9999636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01254951807448323,"score_gpt":0.2584855972310253,"score_spread":0.245936079156542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}