{"id":"W2952952213","doi":"10.1158/1078-0432.ccr-18-3399","title":"Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; University of Texas MD Anderson Cancer Center; National Institutes of Health","keywords":"KRAS; Farnesyltransferase; Cancer research; Pancreatic cancer; Prenylation; Cancer; PI3K/AKT/mTOR pathway; Carcinogenesis; EGFR inhibitors; Apoptosis; Mutant; Biology; Epidermal growth factor receptor; Medicine; Colorectal cancer; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164231,0.000494124,0.0003488015,0.0002155843,0.0001533834,0.00021297,0.0002218327,0.0002770575,0.001392143],"category_scores_gemma":[0.00008611899,0.0001215727,0.0002929776,0.0001747547,0.0001682769,0.0001278272,0.0001520739,0.0007637587,0.0003506627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002859574,"about_ca_system_score_gemma":0.0002842476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000270952,"about_ca_topic_score_gemma":0.0005581066,"domain_scores_codex":[0.999895,0.00001679417,0.000009571087,0.00002162717,0.00002765223,0.00002936877],"domain_scores_gemma":[0.9999409,0.000008858699,0.00001283915,0.00001055545,0.000005399152,0.00002152542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008729413,0.0003171556,0.0005392827,0.00004277625,0.00002216857,0.0001148283,0.00001535816,0.0002216494,0.9930803,0.00009219258,0.0001983719,0.004482987],"study_design_scores_gemma":[0.0001280254,0.002347988,0.003401787,0.000003587255,0.00003736773,0.0007138795,0.00001778804,0.001199225,0.9899165,0.00003793628,0.002191721,0.000004166706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997269,0.0004492769,0.0009495952,0.00008173229,0.00002338822,0.00004356936,0.0002196486,0.0001051995,0.0008585204],"genre_scores_gemma":[0.9963258,0.0003230466,0.001237151,0.00004796076,0.00000764721,0.00004079186,0.0005562991,0.00001191056,0.001449464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001392143,"threshold_uncertainty_score":0.004657209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05554643379333524,"score_gpt":0.383106300371298,"score_spread":0.3275598665779628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}