{"id":"W2952975510","doi":"10.1182/blood-2019-122765","title":"Randomized, Open-Label, Non-Inferiority, Phase 3 Study of Subcutaneous (SC) Versus Intravenous (IV) Daratumumab (DARA) Administration in Patients with Relapsed or Refractory Multiple Myeloma: Columba Update","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Daratumumab; Medicine; Clinical endpoint; Internal medicine; Adverse effect; Refractory (planetary science); Population; Phases of clinical research; Multiple myeloma; Gastroenterology; Randomized controlled trial; Lenalidomide; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004855931,0.001544454,0.00283579,0.0006274927,0.0006440477,0.001916575,0.001222999,0.001875748,0.01147382],"category_scores_gemma":[0.002245941,0.0007843336,0.002384751,0.0009324294,0.001067831,0.00121694,0.0005050121,0.004590707,0.00174854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001575457,"about_ca_system_score_gemma":0.002960431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001544617,"about_ca_topic_score_gemma":0.006217158,"domain_scores_codex":[0.9982921,0.001113173,0.00006815594,0.0001707317,0.00017885,0.0001768989],"domain_scores_gemma":[0.9981812,0.0004710449,0.0005055876,0.000132908,0.0001985807,0.0005105905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9187455,0.02143494,0.002169588,0.001426764,0.002207562,0.0001034664,0.0001659111,0.0004231172,0.01033998,0.0002541622,0.004891226,0.03783783],"study_design_scores_gemma":[0.9374648,0.05300866,0.00397496,0.00007398507,0.0006097299,0.0000637391,0.00002967577,0.0003169119,0.0004410679,0.0001535896,0.003843659,0.00001919857],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9211043,0.02688816,0.003613376,0.005568348,0.00153021,0.02392943,0.007241926,0.0006003437,0.009523885],"genre_scores_gemma":[0.9459187,0.009004653,0.004094342,0.005423896,0.0009908495,0.02140668,0.004604158,0.0001154343,0.008441251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01147382,"threshold_uncertainty_score":0.03838378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02802858378734787,"score_gpt":0.3247151012838969,"score_spread":0.2966865174965491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}