{"id":"W2953005120","doi":"10.1021/ol061373t","title":"Selectively Substituted Thiophenes and Indoles by a Tandem Palladium-Catalyzed Multicomponent Reaction","year":2006,"lang":"en","type":"article","venue":"Organic Letters","topic":"Sulfur-Based Synthesis Techniques","field":"Chemistry","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Palladium; Chemistry; Tandem; Catalysis; Alkylation; Surface modification; Combinatorial chemistry; Sequence (biology); Heck reaction; Organic chemistry; Coupling reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127196,0.0002431082,0.0002299248,0.00007024093,0.0001298829,0.00005978692,0.0001578401,0.0001528168,0.00009143994],"category_scores_gemma":[0.0000611631,0.0002411745,0.00005080117,0.0001441276,0.0001004019,0.0001439167,0.00003751569,0.0002065551,0.00001837567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002592886,"about_ca_system_score_gemma":0.00002829371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004414789,"about_ca_topic_score_gemma":0.00004419803,"domain_scores_codex":[0.9988008,0.00003546106,0.0002520056,0.0004051581,0.000218526,0.0002880961],"domain_scores_gemma":[0.9993563,0.0001428015,0.0001379518,0.0002668758,0.00003374933,0.00006229215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002927612,0.00006537054,0.005623805,0.00002596228,0.00003758805,0.000008238548,0.00009105571,4.384724e-7,0.9906786,0.00001011724,0.003014549,0.0004149813],"study_design_scores_gemma":[0.000625374,0.000003658347,0.006650588,0.00004191355,0.0000345187,0.00001959197,0.00004161225,0.00001929897,0.9908673,0.0000405808,0.001374651,0.0002808731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971969,0.0001393419,0.0005625549,0.001202983,0.00003504207,0.00009956311,0.00001443721,0.000516968,0.0002321735],"genre_scores_gemma":[0.9989108,0.0000255908,0.000473039,0.0002429871,0.0001522325,0.00003051805,0.00008362661,0.00005320283,0.00002800519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001713862,"threshold_uncertainty_score":0.9834811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006666464428151896,"score_gpt":0.1983989619037898,"score_spread":0.1917324974756379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}