{"id":"W2953038935","doi":"10.1016/j.neo.2018.08.001","title":"DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling","year":2018,"lang":"en","type":"article","venue":"Neoplasia","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; National Cancer Institute; National Institutes of Health; Institut National Du Cancer; Ligue Contre le Cancer; Michigan State University; Van Andel Research Institute","keywords":"Biology; Cell biology; Cell cycle checkpoint; Minichromosome maintenance; G2-M DNA damage checkpoint; DNA replication; Control of chromosome duplication; Mitosis; Exonuclease; CHEK1; DNA damage; Cell cycle; Genetics; DNA; Gene; DNA polymerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107531,0.0006719025,0.000378174,0.0003691556,0.0004471967,0.0005488649,0.0002571214,0.0003587973,0.001950915],"category_scores_gemma":[0.0001262965,0.0001756925,0.0003695588,0.0001794284,0.0003130572,0.0004801311,0.0004423926,0.0004323184,0.0008599959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008103155,"about_ca_system_score_gemma":0.0003745297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003035601,"about_ca_topic_score_gemma":0.0004068708,"domain_scores_codex":[0.9998682,0.000007783367,0.00001366571,0.00004845861,0.00002611786,0.00003578973],"domain_scores_gemma":[0.9998895,0.000007141733,0.00002977352,0.00001698957,0.00001939664,0.00003711376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001767637,0.00002826419,0.001742435,0.0002020655,0.00001460024,0.0002190072,0.0000142235,0.0001581258,0.9925598,0.0005909188,0.0001356928,0.004158146],"study_design_scores_gemma":[0.000008422175,0.0000609756,0.007302593,0.000008865372,0.00001264486,0.0005554346,0.00002438523,0.0003718303,0.9846743,0.0002208924,0.006752082,0.000007491116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498185,0.02380812,0.01698541,0.000487941,0.0002813647,0.00005173324,0.001431803,0.0003425412,0.006792657],"genre_scores_gemma":[0.987304,0.002821365,0.002456647,0.00004707215,0.00001986664,0.00001597912,0.001031486,0.00002129214,0.00628229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001950915,"threshold_uncertainty_score":0.00652647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331839296892931,"score_gpt":0.2527938834163443,"score_spread":0.239475490447415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}