{"id":"W2953049244","doi":"10.1002/open.201900116","title":"Insights into Allosteric Control of Human Blood Group A and B Glycosyltransferases from Dynamic NMR","year":2019,"lang":"en","type":"article","venue":"ChemistryOpen","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universität zu Lübeck; Victoria University; University of Alberta; University of Victoria","keywords":"Allosteric regulation; Glycosyltransferase; Chemistry; Group (periodic table); Biochemistry; Enzyme; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002116497,0.0001745161,0.0001372727,0.0001343161,0.000117247,0.0003296611,0.0002050456,0.0001951774,0.001169584],"category_scores_gemma":[0.0003238033,0.000155464,0.0001165176,0.00009065065,0.0003062346,0.0003421026,0.0001891212,0.0003782544,0.0001441543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003247224,"about_ca_system_score_gemma":0.0001293447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006062765,"about_ca_topic_score_gemma":0.0007377807,"domain_scores_codex":[0.999947,0.00001008129,0.000002171447,0.00001452664,0.00001518043,0.00001115838],"domain_scores_gemma":[0.9999228,0.00002888821,0.00002030525,0.000009506265,0.000006455194,0.00001214877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000176231,0.000057713,0.001407889,0.00006697328,0.00001325675,0.0001093375,0.0001286062,0.002890242,0.9822221,0.004470437,0.0004276127,0.008029707],"study_design_scores_gemma":[0.00005288579,0.0002919049,0.01319095,0.00003089729,0.0000323933,0.0003559505,0.0001965502,0.1048844,0.8682452,0.006538104,0.006124106,0.00005660807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817241,0.0007390796,0.01302629,0.0004404756,0.00002207787,0.00001414909,0.0001906375,0.0001616826,0.003681398],"genre_scores_gemma":[0.9971107,0.000323257,0.001932055,0.00006013544,0.000009480832,0.000008184843,0.00008076218,0.00001486909,0.0004604577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001169584,"threshold_uncertainty_score":0.003912687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002751431520072063,"score_gpt":0.2090044076868108,"score_spread":0.2062529761667387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}