{"id":"W2953060083","doi":"10.1136/annrheumdis-2019-eular.6889","title":"OP0183 EFFICACY AND SAFETY OF RIOCIGUAT IN PATIENTS WITH EARLY DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS AND INTERSTITIAL LUNG DISEASE (SSC-ILD): RESULTS FROM THE PHASE IIB RISE-SSC STUDY","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Riociguat; Medicine; DLCO; Interstitial lung disease; Vital capacity; Internal medicine; Clinical endpoint; Placebo; Population; Connective tissue disease; Gastroenterology; Pulmonary function testing; Scleroderma (fungus); Diffusing capacity; Pulmonary hypertension; Lung; Pathology; Clinical trial; Disease; Chronic thromboembolic pulmonary hypertension; Lung function; Autoimmune disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00106699,0.001033517,0.002418195,0.0002518184,0.0001953662,0.000974352,0.0005740648,0.0008973629,0.001806073],"category_scores_gemma":[0.0008026157,0.00031275,0.00152327,0.0003224577,0.0005606603,0.0006167805,0.0002017163,0.002201341,0.0005883667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005204764,"about_ca_system_score_gemma":0.0005893327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007689151,"about_ca_topic_score_gemma":0.001810104,"domain_scores_codex":[0.9996105,0.0001811791,0.00002124145,0.00005464802,0.00004104681,0.00009153653],"domain_scores_gemma":[0.9996037,0.0001225366,0.00008925693,0.00003058771,0.00003355777,0.0001203108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6882609,0.01174713,0.01675335,0.0021092,0.004804938,0.0004524199,0.0001936607,0.002404869,0.02540362,0.0004711647,0.006539482,0.2408593],"study_design_scores_gemma":[0.6611364,0.2233368,0.09856959,0.0002274746,0.00486626,0.0007275368,0.000185776,0.002149933,0.003324253,0.0005092101,0.004874695,0.00009211431],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810119,0.01415354,0.0002947221,0.0005196772,0.0001192025,0.0002783375,0.0008674997,0.0001296406,0.002625504],"genre_scores_gemma":[0.9923519,0.003628721,0.0003425547,0.0008052877,0.0001379382,0.0001959125,0.001441826,0.0000285746,0.001067297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002418195,"threshold_uncertainty_score":0.006041944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01947641673136575,"score_gpt":0.2620097766475351,"score_spread":0.2425333599161693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}