{"id":"W2953073283","doi":"10.3389/fimmu.2019.01414","title":"What Defines NK Cell Functional Fate: Phenotype or Metabolism?","year":2019,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"Ontario Ministry of Health and Long-Term Care; Canadian Institutes of Health Research; Government of Ontario","keywords":"Biology; Cell biology; Effector; Phenotype; Cell metabolism; Cell; Immune system; Cell fate determination; Natural killer cell; Cell type; Cytotoxic T cell; Immunology; Transcription factor; In vitro; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003204693,0.0008693768,0.002989363,0.001214186,0.0001848939,0.00008652414,0.0006689496,0.002103022,0.006301783],"category_scores_gemma":[0.0001223044,0.0006819753,0.0007298503,0.000631011,0.0003271005,0.0006057174,0.0002681608,0.002059394,0.009666213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003583976,"about_ca_system_score_gemma":0.0005569974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005793933,"about_ca_topic_score_gemma":0.00001128625,"domain_scores_codex":[0.9958414,0.0009646248,0.001294928,0.0009640603,0.00006855055,0.0008663826],"domain_scores_gemma":[0.9978898,0.000297493,0.0007518966,0.0009090595,0.0001287011,0.00002309773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009361436,0.0002329201,0.000009319499,0.002582192,0.001423615,0.00001385488,0.0001363921,0.000003589173,0.0003378951,0.0002350064,0.1989886,0.7951005],"study_design_scores_gemma":[0.001515641,0.0001852625,0.00002073512,0.001851526,0.000787682,0.0002065574,0.0006392011,0.000001290074,0.0001549576,0.00003999015,0.9939145,0.0006825898],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001051364,0.8467203,0.0004640037,0.00004686879,0.1502003,0.0007698677,0.000016345,0.0001116952,0.001660103],"genre_scores_gemma":[0.000005409136,0.8552895,0.0001721987,0.0001632813,0.0001894375,0.0001959351,0.001772901,0.0001039184,0.1421075],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7949259,"threshold_uncertainty_score":0.9995632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03133732639658086,"score_gpt":0.2626531814844011,"score_spread":0.2313158550878203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}