{"id":"W2953100444","doi":"10.1200/po.19.00014","title":"Evaluation of Commercial Circulating Tumor DNA Test in Metastatic Prostate Cancer","year":2019,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"China Scholarship Council; Tulane University","keywords":"Prostate cancer; Concordance; Somatic cell; COLD-PCR; Germline mutation; Germline; Biology; Digital polymerase chain reaction; Allele; Cancer research; DNA sequencing; Mutation; Gene; Cancer; Genetics; Oncology; Medicine; Point mutation; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001302329,0.0001068697,0.0002485506,0.00007481978,0.00002096596,0.000007822187,0.0001290249,0.00008238333,0.0001707683],"category_scores_gemma":[0.001002947,0.0001048417,0.00005564574,0.000114675,0.00003837874,0.000004015039,0.0001146189,0.00008555772,0.00001478973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001619729,"about_ca_system_score_gemma":0.000777992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001866702,"about_ca_topic_score_gemma":0.001258353,"domain_scores_codex":[0.9987096,0.0001809485,0.0003815083,0.0002836573,0.0002618201,0.0001825072],"domain_scores_gemma":[0.9989378,0.0002340901,0.0002208989,0.0002519304,0.0003135854,0.00004171388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002276068,0.0003703049,0.09432195,0.0000359279,0.00004660373,0.000005172331,0.0003394267,0.01036278,0.6187883,0.00005051616,0.001066117,0.2743853],"study_design_scores_gemma":[0.01838433,0.005381788,0.5571312,0.0003009167,0.0005010842,0.00006239793,0.0007548352,0.03402855,0.2966731,0.003556575,0.08218979,0.001035499],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956674,0.0008562593,0.00003866356,0.000154702,0.0004169896,0.0006556528,0.00005618059,0.000002924801,0.002151202],"genre_scores_gemma":[0.9987404,0.0001877631,0.0005089932,0.000245677,0.00008846304,0.0001000453,0.00004950017,0.0000161995,0.00006289517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4628092,"threshold_uncertainty_score":0.427532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03189104624185123,"score_gpt":0.3567748904495084,"score_spread":0.3248838442076572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}