{"id":"W2953124185","doi":"10.1158/1078-0432.ccr-17-1928","title":"Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of British Columbia; Ontario Institute for Cancer Research; BC Cancer Agency","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Canadian Cancer Society Research Institute; National Institutes of Health; Terry Fox Research Institute","keywords":"Ponatinib; Biology; SMARCA4; Cancer research; Ovarian cancer; Kinase; Pharmacology; Cancer; Dasatinib; Cell biology; Genetics; Epigenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001229685,0.0001204352,0.0002056715,0.00003644839,0.0001085069,0.00001295203,0.0003044344,0.0002221875,0.00009917728],"category_scores_gemma":[0.0004045106,0.00009044795,0.0001361852,0.000306845,0.0005863225,0.000005840968,0.0003609813,0.0005027614,0.00001637977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007314357,"about_ca_system_score_gemma":0.0006288131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00131683,"about_ca_topic_score_gemma":0.001572334,"domain_scores_codex":[0.9980614,0.0004531869,0.0003819798,0.0004684867,0.0002849226,0.0003500058],"domain_scores_gemma":[0.9987342,0.0001006475,0.00009894794,0.0005568254,0.0004388406,0.00007054516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001271909,0.0004826836,0.04768507,0.0001025132,0.0000179133,0.00000718873,0.0001250662,0.00006191041,0.9372469,0.00001268429,0.003281278,0.009704951],"study_design_scores_gemma":[0.001683704,0.000883633,0.07867926,0.0001023834,0.00001142471,0.000003658778,0.00008452541,0.001049137,0.914483,0.0001766299,0.002671052,0.000171656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966593,0.00086371,0.00004872732,0.0003335139,0.0003486844,0.0003339697,0.000035081,0.000005294844,0.001371748],"genre_scores_gemma":[0.9978959,0.0004764654,0.0002194223,0.0002335059,0.0005918953,0.00003292652,0.00001091522,0.00002221701,0.0005167687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03099419,"threshold_uncertainty_score":0.368836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1761583149082201,"score_gpt":0.4495610062936092,"score_spread":0.2734026913853891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}