{"id":"W2953124185","doi":"10.1158/1078-0432.ccr-17-1928","title":"Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of British Columbia; Ontario Institute for Cancer Research; BC Cancer Agency","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Canadian Cancer Society Research Institute; National Institutes of Health; Terry Fox Research Institute","keywords":"Ponatinib; Biology; SMARCA4; Cancer research; Ovarian cancer; Kinase; Pharmacology; Cancer; Dasatinib; Cell biology; Genetics; Epigenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132554,0.0002327718,0.0004164945,0.0002109026,0.0001561059,0.0002990735,0.000198783,0.0002193722,0.001838607],"category_scores_gemma":[0.0001714067,0.0000898885,0.0002965157,0.000257538,0.0001367567,0.0001420404,0.0001554053,0.0004854035,0.0003755983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003199165,"about_ca_system_score_gemma":0.0003044693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006702726,"about_ca_topic_score_gemma":0.0018637,"domain_scores_codex":[0.9999039,0.0000118059,0.00001314547,0.000014286,0.00003021414,0.00002666938],"domain_scores_gemma":[0.9999408,0.00001172024,0.00001082058,0.00000900113,0.000012631,0.00001498846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006168192,0.0003284532,0.001128746,0.000209775,0.00004306848,0.0002028542,0.0000225288,0.0004975996,0.9812645,0.0001125875,0.0004908802,0.01508228],"study_design_scores_gemma":[0.0004451428,0.004738392,0.01327745,0.00001006609,0.00008636016,0.002188172,0.00004850435,0.001968043,0.9695495,0.00009254646,0.007583032,0.00001289116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930686,0.002247733,0.001176854,0.0001591303,0.0000335896,0.0001200488,0.0007193667,0.0001488661,0.00232581],"genre_scores_gemma":[0.9958476,0.0008412289,0.0008049243,0.00005065355,0.000004782753,0.00003920655,0.001046089,0.00001278526,0.001352734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001838607,"threshold_uncertainty_score":0.006150723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1761583149082201,"score_gpt":0.4495610062936092,"score_spread":0.2734026913853891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}