{"id":"W2953126287","doi":"10.1093/toxsci/kfz128","title":"Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned With the Zebrafish Embryotoxicity Test","year":2019,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Animal testing and alternatives","field":"Veterinary","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Center for Alternatives to Animal Testing, Johns Hopkins Bloomberg School of Public Health","keywords":"Protocol (science); Test (biology); Systematic review; Computer science; MEDLINE; Medicine; Alternative medicine; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7861299,0.004950269,0.0132948,0.03436555,0.00643362,0.0273388,0.01504106,0.01411935,0.006494663],"category_scores_gemma":[0.8286492,0.005969237,0.01440177,0.03594403,0.02105085,0.02444048,0.01917634,0.02213766,0.003242768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.04050763,"about_ca_system_score_gemma":0.1780738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01233135,"about_ca_topic_score_gemma":0.03684816,"domain_scores_codex":[0.1054215,0.7480919,0.09507445,0.01175439,0.03786599,0.001791797],"domain_scores_gemma":[0.07540091,0.7885292,0.0239905,0.03704296,0.07182521,0.003211291],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0005869869,0.0002383924,0.002661603,0.5785065,0.009235002,0.0008757552,0.02428906,0.004934278,0.001201526,0.09916846,0.0380667,0.2402359],"study_design_scores_gemma":[0.002251111,0.0007449637,0.002410336,0.6535086,0.008563117,0.0008676935,0.009172714,0.01075601,0.001597104,0.165659,0.1434253,0.001044078],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.002996027,0.1097538,0.550446,0.1612392,0.01179075,0.1518637,0.003739016,0.001481515,0.00669007],"genre_scores_gemma":[0.01432178,0.02070632,0.8075884,0.01401883,0.0008109513,0.1411785,0.0006811126,0.000181115,0.0005129822],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.2138701,"threshold_uncertainty_score":0.2939048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3863460490616145,"score_gpt":0.4944297105676552,"score_spread":0.1080836615060407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}