{"id":"W2953152748","doi":"10.1038/s41598-018-29973-8","title":"A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Dartmouth College; Centre Hospitalier Universitaire de Québec; Government of Canada; Fondation CHU de Québec; Audrey and Theodor Geisel School of Medicine at Dartmouth; Université Laval","keywords":"Niclosamide; Candida albicans; Biology; Biofilm; Corpus albicans; Microbiology; Yeast; Pathogenic fungus; Antimicrobial; Biochemistry; Bacteria; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001008671,0.0004756135,0.000314115,0.0003879904,0.0001470248,0.0001797642,0.0001985553,0.0002350919,0.001501971],"category_scores_gemma":[0.0001449646,0.0001433565,0.000282751,0.0002377373,0.0001381103,0.0001191601,0.0001784395,0.000216739,0.0003092304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404679,"about_ca_system_score_gemma":0.0002004535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005990627,"about_ca_topic_score_gemma":0.001810563,"domain_scores_codex":[0.9998914,0.00001427765,0.000006740148,0.00002010878,0.00004682451,0.00002052333],"domain_scores_gemma":[0.9999179,0.00001800302,0.000018964,0.000007577485,0.00001792495,0.00001970412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009489753,0.00006888474,0.0004018567,0.00005633173,0.00001151432,0.00007453233,0.000009343568,0.0001723838,0.9946439,0.00003692814,0.00005121833,0.004378294],"study_design_scores_gemma":[0.00006394248,0.002717015,0.008445606,0.0000152901,0.00005816597,0.0004531279,0.00003150932,0.0008905284,0.9842031,0.00003819447,0.003071284,0.00001214676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900252,0.002150682,0.00280719,0.0001002383,0.00002077763,0.0001663687,0.001036909,0.0001340577,0.003558515],"genre_scores_gemma":[0.9880357,0.002595768,0.003738974,0.00009963272,0.00001156358,0.00008613739,0.001738471,0.00002418198,0.003669573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501971,"threshold_uncertainty_score":0.005024612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808603703528936,"score_gpt":0.2534012858465273,"score_spread":0.2353152488112379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}