{"id":"W2953153416","doi":"10.1002/chin.200606110","title":"Diastereoselective Synthesis of Pyrrolidines via the Yb(OTf)<sub>3</sub> Catalyzed Three‐Component Reaction of Aldehydes, Amines, and 1,1‐Cyclopropanediesters.","year":2006,"lang":"en","type":"article","venue":"ChemInform","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Catalysis; Component (thermodynamics); Combinatorial chemistry; Organic chemistry; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001443018,0.0003420327,0.0004907963,0.000106376,0.0001071968,0.00002170222,0.0002454464,0.0002003594,0.0000315891],"category_scores_gemma":[0.0001047698,0.0002663731,0.0001505124,0.0002288146,0.0002333789,0.0002431376,0.0001272036,0.0002148737,0.000007078147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00013258,"about_ca_system_score_gemma":0.00004182174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004982745,"about_ca_topic_score_gemma":0.0004517758,"domain_scores_codex":[0.9982589,0.000001969453,0.0006763327,0.0003278976,0.0004092661,0.0003256107],"domain_scores_gemma":[0.9982143,0.0002862965,0.0006640862,0.0005362352,0.0002270768,0.00007199177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001288116,0.00007838092,0.0003366723,0.0004953883,0.00007277494,0.000002395368,0.0003092171,0.00000104017,0.8963919,0.00004090237,0.0000871636,0.1020554],"study_design_scores_gemma":[0.0004411607,0.00002300512,0.003283713,0.0001348216,0.0001643765,0.0001081384,0.0007017137,0.00005003477,0.993875,0.0002298298,0.0007219077,0.0002662925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738654,0.0003591172,0.00002564136,0.00006903512,0.00009522145,0.0002381833,0.00005213935,0.00008805269,0.02520721],"genre_scores_gemma":[0.9991639,0.0001515343,0.00007058998,0.00000805266,0.0001794616,0.00009901216,0.000111483,0.00004449063,0.0001715249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1017891,"threshold_uncertainty_score":0.9999788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007139443272915024,"score_gpt":0.1919251533223214,"score_spread":0.1847857100494064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}